Effects of Danqing Soft Capsule on Rats with Non-alcoholic Fatty Liver Disease
|更新时间:2024-01-04
|
Effects of Danqing Soft Capsule on Rats with Non-alcoholic Fatty Liver Disease
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 11, Pages: 175-178(2011)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2011
稿件说明:
移动端阅览
LIU Rui, LI Jin-ping, FAN Juan-juan, et al. Effects of Danqing Soft Capsule on Rats with Non-alcoholic Fatty Liver Disease[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 175-178.
DOI:
LIU Rui, LI Jin-ping, FAN Juan-juan, et al. Effects of Danqing Soft Capsule on Rats with Non-alcoholic Fatty Liver Disease[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 175-178.DOI:
Effects of Danqing Soft Capsule on Rats with Non-alcoholic Fatty Liver Disease
Objective: To observe the effects of Danqing Soft Capsule (DSC) on rat with non-alcoholic fatty liver (NAFLD). Method: The SD rats were randomly divided into control group
model group
DSC high dose group
medium dose group
low dose group
and polyene phosphatidyl choline (PPC) group.Non-alcoholic fatty liver disease model in SD rats was established with high fat diet.DSC high dose group
medium dose group and low dose group were intervened with different concentrations of DSC
which are respectively equivalent to petroleum ether extract of salvia 0.456
0.228
0.114 g ·kg-1.PPC group was intervened with PPC of 0.159 g ·kg-1ig.Control group and model group were administered the same volume (1.2 mL ·kg-1
ig) of distilled water.After treatment for 4 weeks
rat liver pathological changes
TG
TC level
and blood lipids levels were observed. Result: The levels of TC
TG
LDL-C in serum and the levels of TG and TC in liver of control group
traditional Chinese medicine (TCM) groups and western medicine (WM) group were significantly lower than those of model group (P<0.01
P<0.05).Compared with those in model group
the degrees of fatty degeneration of liver cells in TCM groups and WM group were significantly improved (P<0.01). Conclusion: DSC can reduce the level of TG
TC
LDL in serum as well as the level of TG and TC in liver.It can improve the steatosis of liver in rats with NAFLD.
Effects of Danqing Soft Capsule on Insulin Resistance and Leptin Resistance in Rats with Non-alcoholic Fatty Liver Disease
Effect of Borneol on Pharmacodynamics,Pharmacokinetics and Brain Tissue Distribution of Main Active Ingredients of Jiaotaiwan in Depression Model Rats
Mechanism of Traditional Chinese Medicine in Regulating Gut Microbiota in Treating Metabolic-associated Fatty Liver Disease
Investigation of Effect of Different Processed Products of Atractylodes chinensis Rhizoma on Rats with Spleen Deficiency Based on Pharmacodynamics and Metabolomics
Analgesic Effect and Action Mechanisms of Wenjing Zhitong Prescription on Primary Dysmenorrhea
Related Author
WU Juan-juan
YU Meishuang
DAI Guoliang
HANG Huaxi
YE Yu
WANG Yiran
SHAO Xuewen
JU Wenzheng
Related Institution
Affiliated Hospital of Nanjing University of Chinese Medicine
The Sixth People's Hospital of Shanghai Jiao Tong University
Henan University of Chinese Medicine
School of Pharmacy,Liaoning University of Traditional Chinese Medicine
College of Chinese Medicine, Beijing Research Institute of Chinese Medicine, College of Life Science, Beijing University of Chinese Medicine