Hypoglycemic Effect of Total Polyphenols from Seeds of  in Diabetic Mice

XING Sha-sha; CHEN Chao

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Hypoglycemic Effect of Total Polyphenols from Seeds of in Diabetic Mice

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- Hypoglycemic Effect of Total Polyphenols from Seeds of in Diabetic Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 11, Pages: 169-171(2011)
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- Published：2011
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XING Sha-sha, CHEN Chao. Hypoglycemic Effect of Total Polyphenols from Seeds of in Diabetic Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 169-171.
DOI：

XING Sha-sha, CHEN Chao. Hypoglycemic Effect of Total Polyphenols from Seeds of in Diabetic Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 169-171. DOI：

摘要

目的: 研究香椿子总多酚对糖尿病小的降血糖作用。方法: 一次性ip链脲佐菌素制造糖尿病模型。将香椿子总多酚分低、中、高剂量组 (60

100 mg ·kg-1)连续ig 14 d

第15 d用葡萄糖氧化酶法测空腹血糖

同时测定多酚对正常小鼠血糖影响。糖尿病小鼠处死后取脏器

测定小鼠脏器指数、肝脏超氧化物歧化酶(SOD)活性

丙二醛(MDA)含量变化。结果: 香椿子总多酚能降低链脲佐菌素诱导的糖尿病小鼠的血糖

对正常小鼠血糖没有降低作用。香椿子多酚能降低糖尿病小鼠肝脏脏器指数(P<0.05)

降低肝脏MDA含量(P<0.05)

增加SOD活性(P<0.05)。结论: 香椿子多酚对链脲佐菌素所致糖尿病模型小鼠有降血糖作用。

Abstract

Objective: To study hypoglcemic effect of total polyphenols from seeds of Toona sinensis (STP)on diabetic mice model. Method: Diabetic model was induced by once intraperitoneal injection of STZ.Diabetic mice were randomly divided into model group

Metformin group and high-

middle-and low-doses of STP groups (100

60 mg ·kg-1).All groups were fed for 14 consecutive days

and then the blood glucose were detected by glucose oxidizes on the fifteenth day.The organ index was also detected. Result: The blood glucose level of the diabetic mice was significantly decreased.STP could increase liver index significantly(P<0.05).STP could decrease MDA(P<0.05) and increase SOD (P<0.05) in liver homogenate of the diabetic mice significantly. Conclusion: STP can significantly decrease the blood glucose level in mice with diabetes induced by STZ.

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