Influence of Shenqi Feibao on Serum SOD and MDA in Rats with COPD and Qi Deficiency
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Influence of Shenqi Feibao on Serum SOD and MDA in Rats with COPD and Qi Deficiency
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 4, Pages: 160-162(2011)
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Published:2011
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GENG Xiao-zhao, XIE Da-sha, LIU Liang-li, et al. Influence of Shenqi Feibao on Serum SOD and MDA in Rats with COPD and Qi Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 160-162.
DOI:
GENG Xiao-zhao, XIE Da-sha, LIU Liang-li, et al. Influence of Shenqi Feibao on Serum SOD and MDA in Rats with COPD and Qi Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 160-162.DOI:
Influence of Shenqi Feibao on Serum SOD and MDA in Rats with COPD and Qi Deficiency
参芪肺宝高剂量组使"肺气虚证"大鼠血清MDA显著降低( P <0.05);参芪肺宝高、低剂量组血清SOD活性无显著性变化。 结论 :参芪肺宝有保护气道黏膜
减轻肺损伤的作用
能降低血清MDA含量
可在一定程度上阻止"肺气虚证"模型的形成。
Abstract
Objective: To investigate the influence of Shenqi Feibao on rat model of chronic pulmonary disease(COPD)and Qi Deficiency. Moethod: Wistar rat was employed in the study.COPD with Qi deficiency model was estbablished by smoke inhalation combined with papnin administration.Shenqi Feibao treatment was carried out meanwhile as the model was establishing.Two dose groups were designed as 12 and 6 g ·kg-1 daily for 60 days.The general conditions
the changes in bronchial and lung and serum SOD
MDA of the rats were observed and determined. Rsult: Shenqi Feibao could improve the systemic and respiratory conditions for the model rats
alleviate the injury in bronchina and lung tissues siginficantly
The high dose of the alleviate the injury in brochinal and lung tissues significantly.The high dose of the drug could significantly decrease MDA level compared with that of the model group (P<0.05).However
the level of SOD in the treatment groups did not change significantly compared with that of the model. Conclusion: Shenqi Feibao has the effect of protectiong airway mucosa
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Related Author
GENG Xiao-zhao1
XIE Da-sha1
LIU Liang-li2
LI Yuan-qing2
XIN Jingjing
WANG Tongxing
HAN Ningxin
YANG Yang
Related Institution
First Affiliated Hopital,Guiyang College of Tranditional Chinese Medicine
Guiyang College of Tranditional Chinese Medicine
Key Laboratory of State Administration of Traditional Chinese Medicine (Cardio-Cerebral Vessel Collateral Disease)
State Key Laboratory for Innovation and Transformation of Luobing Theory