Efficacy Evaluation of Transdermal Absorption Enhancementfor Four Kinds of Traditional Chinese Medicineon Different Structure Substance
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Efficacy Evaluation of Transdermal Absorption Enhancementfor Four Kinds of Traditional Chinese Medicineon Different Structure Substance
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 12, Pages: 34-38(2011)
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Published:2011
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ZHAO Hua, LIN Jie, HE Cong-fen, et al. Efficacy Evaluation of Transdermal Absorption Enhancementfor Four Kinds of Traditional Chinese Medicineon Different Structure Substance[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 34-38.
DOI:
ZHAO Hua, LIN Jie, HE Cong-fen, et al. Efficacy Evaluation of Transdermal Absorption Enhancementfor Four Kinds of Traditional Chinese Medicineon Different Structure Substance[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 34-38.DOI:
Efficacy Evaluation of Transdermal Absorption Enhancementfor Four Kinds of Traditional Chinese Medicineon Different Structure Substance
Objective: The efficacy of transdermal absorbent enhancement for four kinds of Chinese traditional medicine Angelica sinensis
Syringa oblata
Salvia miltiorrhiza
Cinnamomum cassia on the different structure substance was evaluated
which will provide the theoretical basis for the selection of Chinese medicine of cosmetics. Method: The guinea pig abdominal skin was used as the skin model; the polysaccharide (seaweed polysaccharide)
peptides (oat peptides) and flavonoids (Licorice flavonoids) were used as the objects to be promoted; azone was used as the positive reference. The experiment of Franz diffusion cell was used to evaluate the transdermal absorbent enhancement of four medicines to the different substance. Result: The efficacy of transdermal absorption enhancement was: A. sinensis>S. oblata>S. miltiorrhiza>azone>C. cassia. The quantity of the transdermal absorption enhancement was investigated
which showed that 0.8% A. sinensis ≥ 1% azone. Conclusion: There were no obvious structure-activity relationships between transdermal absorption enhancement and the targets. The mechanism is concluded to be the theory of stratum corneum structural changing.