Effects of Invigorating Kidney and Regulating Periphery onRats with Pnemature Ovarian Failure and Its Influence onInhibin B and Vascular Endothelial Growth Factor
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Effects of Invigorating Kidney and Regulating Periphery onRats with Pnemature Ovarian Failure and Its Influence onInhibin B and Vascular Endothelial Growth Factor
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 12, Pages: 213-216(2011)
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Published:2011
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ZHANG Da-wei, LI Cui-ping, HUANG Xia, et al. Effects of Invigorating Kidney and Regulating Periphery onRats with Pnemature Ovarian Failure and Its Influence onInhibin B and Vascular Endothelial Growth Factor[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 213-216.
DOI:
ZHANG Da-wei, LI Cui-ping, HUANG Xia, et al. Effects of Invigorating Kidney and Regulating Periphery onRats with Pnemature Ovarian Failure and Its Influence onInhibin B and Vascular Endothelial Growth Factor[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(12): 213-216.DOI:
Effects of Invigorating Kidney and Regulating Periphery onRats with Pnemature Ovarian Failure and Its Influence onInhibin B and Vascular Endothelial Growth Factor
Objective: To study effects of the self-made series of prescriptions of invigorating kidney and regulating periphery. On inhibin B(INHB) and vascular endothelial growth factor(VEGF) in rats with premature ovarian failure(POF). Method: Ninety rats were randomly divided into 9 groups(n=10):the blank control group
model control group
positive control group
the group of high dose Ⅰprescription of invigorating kidney(68.67 g ·kg-1)
the group of low dose Ⅰprescription of invigorating kidney(34.30 g ·kg-1)
the group of high dose Ⅱprescription of invigorating kidney(61.40 g ·kg-1)
the group of low dose Ⅱ prescription of invigorating kidney(30.70 g ·kg-1)
the group of high dose prescription of invigorating kidney and regulating menstruatinon
the group of low dose prescription of invigorating kidney and regulating menstruatinon.In addition to the blank control group
the other groups were induced as POF models by CTX.After 20 days’ treatments
the serum levels of INHB and VEGF were detected
and structure of ovary was observed under the lightmicroscope. Result: The method of invigorating kidney and regulating menstruation could obviously increase the serum levels of INHB and EGF
and increase all kinds of follicles and the quantity of the yellow body organization of the ovary. Conclusion: The method of invigorating kidney could improve the ability of ovarian reserve in POF rats.This might be one of the mechanisms of early intervention for premature ovarian failure.
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