Effect of Xuanfu Daizhe Decoction on Motilin,Gastrin and Vasoactive Intestinal Peptide in Blood and Tissuein Rats with Low Gastric Motility
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Effect of Xuanfu Daizhe Decoction on Motilin,Gastrin and Vasoactive Intestinal Peptide in Blood and Tissuein Rats with Low Gastric Motility
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 11, Pages: 161-164(2011)
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Published:2011
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SHUI Dian-kui, XIE Sheng. Effect of Xuanfu Daizhe Decoction on Motilin,Gastrin and Vasoactive Intestinal Peptide in Blood and Tissuein Rats with Low Gastric Motility[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 161-164.
DOI:
SHUI Dian-kui, XIE Sheng. Effect of Xuanfu Daizhe Decoction on Motilin,Gastrin and Vasoactive Intestinal Peptide in Blood and Tissuein Rats with Low Gastric Motility[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 161-164.DOI:
Effect of Xuanfu Daizhe Decoction on Motilin,Gastrin and Vasoactive Intestinal Peptide in Blood and Tissuein Rats with Low Gastric Motility
Objective: To observe the effect for Xuanfu Daizhe Decoction (XFDZD) on motilin (MTL)
gastrin (GAS) and vasoactive intestinal peptide (VIP) content in blood and tissue in rats with low gastric motility. Method: Seventy Wistar rats were divided into normal group (10 rats) and model group (60 rats) at random.Each rat of model group was irritated stomach with liquorice decoction (10 g ·kg-1).After stomach irritation
model group were divided into model group of 3 days
model group of 7 days
low
medium
high dosage groups of XFDZD
and the group of domperidone.The stomach with low gastric motility was irritated with domperidone
and the treatment groups were treated with XFDZD at different doses.Then the content of MTL
GAS
VIP in blood and gastric antrum was tested with radioimmunopercipitation. Result: Liquorice decoction could make rat model of low gastric motility.XFDZD could make MTL
GAS content increase in rat’s blood and organization
at the same time make VIP content reduce
campared with model groups
there were all significance difference (P<0.05 or P<0.01). Conclusion: XFDZD could treat disease of gastrointestinal dismotility by regulating brain-gut peptides content in rat's blood or gastric antrum.