Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice

YAN Hui; SUN Xiao-di; LIU Shou-cheng; SUN Shi-guang; ZHANG Wei-dong; YANG Feng; SHI Qi-rong; XIE Yu-peng; LIU Shuang

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Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice

更新时间：2024-09-23

- Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 4, Pages: 157-159(2011)
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- Published：2011
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YAN Hui, SUN Xiao-di, LIU Shou-cheng, et al. Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 157-159.
DOI：

YAN Hui, SUN Xiao-di, LIU Shou-cheng, et al. Anti-inflammatory and Analgesic Activity of Haijin Huwei San Micro-powder in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 157-159. DOI：

摘要

目的 :考察海金护卫散微粉对小鼠的抗炎及镇痛效果。方法 :实验小鼠分为6组:空白组

阿司匹林(1.4 g ·kg-1)组

海金护卫散普通粉(1.5 g ·kg-1)

海金护卫散微粉(4.5

3.0

1.5 g ·kg-1)组

连续ig 7 d

采用二甲苯致小鼠耳廓肿胀法观察抗炎作用;采用热板法和扭体法观察对小鼠的镇痛作用。结果 :海金护卫散微粉对二甲苯所致小鼠耳廓肿胀的抑制作用明显

呈现出随剂量增加而增强的趋势。与海金护卫散普通粉相当;与阿司匹林相当。海金护卫散微粉能使小鼠痛阈值提高

舔足次数减少;使小鼠扭体潜伏期延长

扭体次数减少。表明海金护卫散微粉具有明显的镇痛作用

与海金护卫散普通粉相当。结论 :海金护卫散微粉对小鼠具有抗炎镇痛作用。

Abstract

Objective: To observe anti-inflammatory and analgesic activity in mice of Haijin Huwei San micro-powder. Method: The model of xylene-induced auricular swelling in mice was used to observe the anti-inflammatory effects.Analgesic effect of Haijin Huwei San micro-powder was investigated by hot plate test and acetic acid writhing test in mice. Result: Haijin Huwei San micro-powder could reduce the degree of tumefaction in auricle

with dose-dependent manner.Could reach the similar effect compared with Haijin Huwei San normal powder and aspirin.The micro-powder Showed analgesia effect demostrated by hot plate method and stretching method

It’s analgesic effect was the same to Haijin Huwei San normal powder. Conclusion: It indicates that Haijin Huwei San micro-powder has significant anti-inflammatory and analgesic effects in mice.

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Related Author

YAN Hui1

SUN Xiao-di1

LIU Shou-cheng2

SUN Shi-guang1

ZHANG Wei-dong1

YANG Feng1

SHI Qi-rong1

XIE Yu-peng1

Related Institution

Department of pharmacy,The General Hospital of Beijing Military Region

Department of pharmacy,The No 266 Hospital of PLA

The Second Cadres Sanatorium,Beijing Military Command

The NATCM Third Grade Laboratory of TCM Preparations，Key Laboratory of Liver and Kidney Diseases （Ministry of Education）， Shanghai Key Laboratory of Traditional Chinese Clinical Medicine， Shuguang Hospital Affiliated to Shanghai University of TCM

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine （TCM）

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