Experimental Studies of Water Extraction of K-CoxB-JN on Anti-stress and Analgesic Activities

ZHANG Bo-nan; HAN Shu-ying; LI Jie; MA Hui-xia; ZHENG Cai-hui; YAO Rong-mei; DONG Xiao-peng; Wang Min; BAO Ju-tai

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Experimental Studies of Water Extraction of K-CoxB-JN on Anti-stress and Analgesic Activities

更新时间：2024-01-04

- Experimental Studies of Water Extraction of K-CoxB-JN on Anti-stress and Analgesic Activities
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 6, Pages: 133-135(2011)
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- Published：2011
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ZHANG Bo-nan, HAN Shu-ying, LI Jie, et al. Experimental Studies of Water Extraction of K-CoxB-JN on Anti-stress and Analgesic Activities[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 133-135.
DOI：

ZHANG Bo-nan, HAN Shu-ying, LI Jie, et al. Experimental Studies of Water Extraction of K-CoxB-JN on Anti-stress and Analgesic Activities[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 133-135. DOI：

摘要

目的: 观察抗柯萨奇B病毒性心肌炎胶囊(K-CoxB-JN)复方水提物镇痛作用和抗应激反应能力。方法: 健康昆明种小鼠随机分为5组

K-CoxB-JN复方水提物高剂量组、中剂量组、低剂量组

20 mL ·kg-1(给药量为9.6

4.8

2.4 g ·kg-1)

分别连续ig给药

并设阳性对照组及正常对照组。采用醋酸和热刺激致疼痛模型

考察其镇痛活性;采用游泳实验和耐缺氧实验

考察其抗应激作用。结果: K-CoxB-JN复方水提物对小鼠抗疲劳、耐缺氧等抗应激能力有一定的增强作用。相对于对照组

高剂量给药组可使小鼠游泳时间延长57 s

耐缺氧存活时间延长12 min;可以明显抑制醋酸引起的扭体次数

延长热板上小鼠舔后足出现的时间。相对于对照组

高剂量给药组可使小鼠扭体次数减少20次;中剂量给药组可使小鼠舔后足时间延长16 s。结论: K-CoxB-JN复方水提物具有明显的镇痛和抗应激作用。

Abstract

Objective: To study the anti-stress and analgesic activities of water extraction of K-CoxB-JN

a compound Chinese medicine for treatment of myocarditis. Method: Water extraction of K-CoxB-JN was consecutively given to healthy Kunming mice with high (9.6 g ·kg-1)

medium (4.8 g ·kg-1) and low dose (2.4 g ·kg-1) ig. At the same time

control group and positive group were set up. Analgesic activity was evaluated in mice model of pain induced by thermal stimulus and acetic acid. Meanwhile

anti-stress activity was evaluated by swimming and anti-hypoxia experiments. Result: Water extraction of K-CoxB-JN could enhance anti-stress capability of anti-fatigue and anti-hypoxia. The number of writhing induced by acetic acid was significantly reduced and the time of licking rear feet induced by hot plate stimulation was prolonged. Conclusion: Water extraction of K-CoxB-JN has good effects of anti-stress and analgesic capability.

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