Objective: To compare the haemostatic mechanism of carbonized and raw Scutellariae Radix

screen effective haemostatic component from the carbonized herb by fevered and bleeding rat models. Method: SD rats were randomly divided into blank control group

model compared group

Yunnan white drug group

raw Scutellariae Radix group

carbonized Scutellariae Radix group and chloroform Scutellariae Radix group.Experimental material was used to ig dose of 20 mL ·g-1 once a day

for 7 days. Prothrombin time (PT)

thrombin time (TT)

activated partial thromboplastin time (APTT)

fibrinogen content (FIB) and hemorheological parameters were examined to study the effects of experimental material on SD rats. Result: The model group had significantly difference with blank control

prolonged PT

TT

APTT

HBV

MBV and LBV to (17.26±1.73) s

(23.15±1.83) s

(22.43±1.93) s

(5.72±0.55) mPa ·s

(7.44±0.78) mPa ·s and (6.59±1.10) mPa ·s. Carbonized Scutellariae Radix and chloroform Scutellariae Radix could significantly shorten the PT

TT and APTT of the fevered and bleeding model rats.PT

TT and APTT of carbonized Scutellariae Radix group and chloroform Scutellariae Radix group was respectively that (14.53±1.45) s

(13.24±1.46) s;(20.91±1.15) s

(18.70±1.44) s and (18.07±0.75) s

(15.59±1.74) s.Compared with the model compared group

P<0.05 or P<0.01.Otherwise

there was no effect on FIB. Conclusion: The chloroform extract is the effective component for hemostasis

and plays roles by ways of endogenous thrombin

extrinsic thrombin and the both

but has no relation with fibrin.The improvement of hemorheological parameters is a basis for hemostasis.