Action of Xinzhi Bimin Capsule in Model of Rats with Allergic Rhinitis and Influence on levels of Interleukin-5 and Eosinophil
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Action of Xinzhi Bimin Capsule in Model of Rats with Allergic Rhinitis and Influence on levels of Interleukin-5 and Eosinophil
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 6, Pages: 217-219(2011)
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Published:2011
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YANG Qing, GAO Li, JIANG Xiao-fang, et al. Action of Xinzhi Bimin Capsule in Model of Rats with Allergic Rhinitis and Influence on levels of Interleukin-5 and Eosinophil[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 217-219.
DOI:
YANG Qing, GAO Li, JIANG Xiao-fang, et al. Action of Xinzhi Bimin Capsule in Model of Rats with Allergic Rhinitis and Influence on levels of Interleukin-5 and Eosinophil[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 217-219.DOI:
Action of Xinzhi Bimin Capsule in Model of Rats with Allergic Rhinitis and Influence on levels of Interleukin-5 and Eosinophil
且与鼻炎康组比较有统计学意义( P <0.05);辛芷鼻敏胶囊组大鼠鼻黏膜EOS计数明显低于模型组和鼻炎康组(P<0.01
P<0.05)。 结论 :辛芷鼻敏胶囊可以减少IL-5水平
减少嗜酸性粒细胞浸润
而起到一定的治疗作用。
Abstract
Objective: To investigate effect of Xinzhi Bimin capsule on the model of rats with allergic rhinitis(AR) and the effect on Interleukin-5(IL-5) and eosinophil(EOS). Method :Fourty rats were randomly divided into control group
sensitized group
the positive control (Beiyankang
3 g ·kg-1)and experimental groups(3.6 g ·kg-1).The rats were sensitized by ovalbumin. Result : IL-5 content in bone marrow of the experimental group was significantly lower than those of the model group and the positive control group(P<0.05); IL-5 content of blood serum in the experimental group was significantly lower than those of the model group and the positive control group(P<0.05); the numbers of EOS
compared with the control group and the model group
there were significant difference(P<0.05). Conclusion : Xinzhi Bimin capsule can reduce IL-5 content of bone marrow and in serum
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FAN Shuyue
WU Luwei
SUN Tongtong
NI Yuying
GAO Jing
CUI Ying
LIU Min
LIU Cuifang
Related Institution
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine
Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences
Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences
China Association of Chinese Medicine
Institute of Otolaryngology & Head and Neck Surgery, Dongzhimen Hospital, Beijing University of Chinese Medicine