Optimize Extraction Process of Wuji Wan by Multi-index Comprehensive Evaluation Method

LAI Jing-yi; ZHANG Zhen-qiu; LIU Feng; LIN Li-li; GAO Chong-jia; LI Yu-heng

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Optimize Extraction Process of Wuji Wan by Multi-index Comprehensive Evaluation Method

更新时间：2024-01-04

- Optimize Extraction Process of Wuji Wan by Multi-index Comprehensive Evaluation Method
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 8, Pages: 26-28(2011)
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- Published：2011
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LAI Jing-yi, ZHANG Zhen-qiu, LIU Feng, et al. Optimize Extraction Process of Wuji Wan by Multi-index Comprehensive Evaluation Method[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 26-28.
DOI：

LAI Jing-yi, ZHANG Zhen-qiu, LIU Feng, et al. Optimize Extraction Process of Wuji Wan by Multi-index Comprehensive Evaluation Method[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 26-28. DOI：

摘要

目的: 采用多指标综合评分法优选戊己丸提取工艺

为戊己丸的生产工艺提供技术参数。方法: 采用正交试验法

以出膏率、总生物碱、芍药苷、吴茱萸碱和吴茱萸次碱的含量为评价指标

通过综合评分优选戊己丸的提取工艺。结果: 提取次数对试验结果有极显著意义

乙醇倍量对试验结果有显著意义

乙醇体积分数和提取时间则无显著意义

综合考察各因素的影响

确定最佳工艺条件为A3B3C3D1

即80%乙醇

10倍量

提取3次

每次1 h。结论: 本试验方法稳定可靠

对戊己丸的生产工艺具有一定的指导和参考意义。

Abstract

Objective: Using multi-index comprehensive evaluation method to provide the production technology parameters of Wuji Wan. Method: The orthogonal test was employed with the index of the rate of extraction and the content of total alkaloid

paeoniflorin

evodiamine and rutaecarpine

optimizing the extraction process of Wuji Wan by multi-index comprehensive evaluation method. Result: Extraction times had much notable effect on experimental results and times

and the amount of ethanol had notable effect on the results. Ethanol concentration and extraction time had no notable effects. Considering the effects of five factors synthetically

the optimum process was A3B3C3D1

that was 80% ethanol

10 times the amount of ethanol

extraction 3 times and 1hour every time. Conclusion: The experimental method was steady and trusty

which will have some instruction meaning and reference value to the production of Wuji Wan.

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Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Tongzhou Campus， Dongzhimen Hospital， Beijing University of Chinese Medicine

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