Animal Model Replication of Proliferative Breast by Homogeneous Design
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Animal Model Replication of Proliferative Breast by Homogeneous Design
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 7, Pages: 204-206(2011)
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Published:2011
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LUO Lun-cai, JI Xiao-ping, HUANG Lan-ya, et al. Animal Model Replication of Proliferative Breast by Homogeneous Design [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 204-206.
DOI:
LUO Lun-cai, JI Xiao-ping, HUANG Lan-ya, et al. Animal Model Replication of Proliferative Breast by Homogeneous Design [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 204-206.DOI:
Animal Model Replication of Proliferative Breast by Homogeneous Design
Objective: To investigate the methods in copying the animal proliferative breast model. Method : We copied the animal proliferative breast model with different experimental programs
according to the theory of homogeneous design. And we evaluated varying degrees of success of these models with such indexes as the diameter of the mammilla
height of the mammilla and pathological dye of the galactophore. Result : Compared with the blank control group
the experimental group of animals’ nipple diameter and height were significantly increased in the breast tissue hyperplasia of mammary glands are typical
with the fifth
sixth group was the most obvious. Conclusion: The optimal conditions for establishing the model appear to be:estradiol benzoate 0.42-0.5mg ·kg-1
the duration for 25-35 days and progesterone 3-4.5 mg ·kg-1
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