Effect of Shenfu Yixin Granule on Heart Failure Rats Myocardial c-fos,c-myc Expression
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Effect of Shenfu Yixin Granule on Heart Failure Rats Myocardial c-fos,c-myc Expression
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 3, Pages: 145-147(2011)
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Published:2011
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WANG Yong-xia, ZHU Ming-jun, ZHU Xin-feng, et al. Effect of Shenfu Yixin Granule on Heart Failure Rats Myocardial c-fos,c-myc Expression[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 145-147.
DOI:
WANG Yong-xia, ZHU Ming-jun, ZHU Xin-feng, et al. Effect of Shenfu Yixin Granule on Heart Failure Rats Myocardial c-fos,c-myc Expression[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 145-147.DOI:
Effect of Shenfu Yixin Granule on Heart Failure Rats Myocardial c-fos,c-myc Expression
c-myc表达。 结果: 21.90 g ·kg-1 ·d-1参附益心颗粒可显著提高心衰大鼠LVEF
降低LVMI
抑制心衰大鼠心肌中c-fos
c-myc表达。 结论: 参附益心颗粒能够通过抑制心衰大鼠心肌中c-fos
c-myc表达
抑制心肌重塑。
Abstract
Objective: To investigate the effect of the Shenfu Yixin Granule on heart failure rats myocardial c-fos
c-myc expression. Method: Hear failure rats were produced by left anterior descending coronary artery occlusion in one hundred thirty heathly male SD rats. Twenty rats obtained the surgery without ligation as sham control. After 8 weeks
rats with left ventricle ejection fraction(LVEF)<50% were randomly Yixin assigned to 5 groups (n=10 in each group): model group
captopril group
losartan group
two groups of Shenfu Yixin Granule(5.48
21.90 g ·kg-1 ·d-1). All the medicine was taken orrally once a day for 4 weeks. The rats in model group and sham control (n=10) were administered equivalent water. After 4 weeks
The LVEF was valued with Color Doppler Ultrasound again. The left ventricular mass index (LVMI) was checked. The expression of c-fos
c-myc were detected respectively by immune-histochemisty technique. Result: Shenfu Yixin Granule(21.90 g ·kg-1 ·d-1) increased the LVEF
decreased LVMI and inhibited the expression of c-fos
c-myc. Conclusion: Shenfu Yixin Granules inhibit the expression of c-fos
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