Multi-center Randomized Double-blind Controlled Clinical Trial on Baoshen Tablets in Treatment of Chronic Renal Failure with Qi and Yin Deficiency and Dampness Syndrome
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Multi-center Randomized Double-blind Controlled Clinical Trial on Baoshen Tablets in Treatment of Chronic Renal Failure with Qi and Yin Deficiency and Dampness Syndrome
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 10, Pages: 259-262(2011)
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Published:2011
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LIU Yu-jie, MA Fang-yu, WANG Yi-ping, et al. Multi-center Randomized Double-blind Controlled Clinical Trial on Baoshen Tablets in Treatment of Chronic Renal Failure with Qi and Yin Deficiency and Dampness Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 259-262.
DOI:
LIU Yu-jie, MA Fang-yu, WANG Yi-ping, et al. Multi-center Randomized Double-blind Controlled Clinical Trial on Baoshen Tablets in Treatment of Chronic Renal Failure with Qi and Yin Deficiency and Dampness Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(10): 259-262.DOI:
Multi-center Randomized Double-blind Controlled Clinical Trial on Baoshen Tablets in Treatment of Chronic Renal Failure with Qi and Yin Deficiency and Dampness Syndrome
Objective: Observation the curative efficacy of Baoshen Tablets curing/therapy Chronic Renal Failure (CRF)with Qi and Yin Deficiency and dampness syndrome. Method: Using the methods of a multicenter
randomized
double-blind double-dummy
parallel control for positive drug
the experimental group 345 cases of patients taking Baoshen Tablets and imitated tablet
the control group of 118 patients taking Shenkangning Tablets and imitated tablet. Observing the changes before and after treatment by the value of TCM syndromes
blood urea nitrogen (BUN)
serum creatinine (SCr)
creatinine clearance rate of endogenous (CCr)
hemoglobin (Hb)
24h urinary protein. Result: The total effective rate of experimental group was 88.12%
and the total effective rate of the control group was 74.58%. The patients of experimental group the value of TCM syndromes
BUN
SCr
24h urine protein were significantly decreased (P <0.05 or P <0.01)
CCr
Hb significantly increased (P<0.01)
the control group on BUN
SCr
Hb
24h urinary protein showed no significant improvement(P<0.01). The Control group of BUN
SCr
Hb
24h urinary protein showed no significant improvement. Conclusion: The Baoshen Tablets can significantly improve the CRF with Qi and Yin Deficiency and dampness syndrome of the clinical manifestations
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