Effects of Xifeng Jingning Tang on Immunologic Function in Mice

LI Yan; XU Rong-qian; WANG Jun-hong; GU Wen-cai; XIA Gui-xuan; ZHANG Jing-jie

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Effects of Xifeng Jingning Tang on Immunologic Function in Mice

更新时间：2024-01-04

- Effects of Xifeng Jingning Tang on Immunologic Function in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 7, Pages: 198-201(2011)
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- Published：2011
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LI Yan, XU Rong-qian, WANG Jun-hong, et al. Effects of Xifeng Jingning Tang on Immunologic Function in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 198-201.
DOI：

LI Yan, XU Rong-qian, WANG Jun-hong, et al. Effects of Xifeng Jingning Tang on Immunologic Function in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 198-201. DOI：

摘要

目的: 研究熄风静宁汤对免疫低下小鼠免疫功能的影响。方法: 环磷酰胺50 mg ·kg-1 ip建立免疫功能低下小鼠模型

熄风静宁汤(3

12 g ·kg-1) ig连续7 d

用碳粒廓清法观察小鼠单核巨噬细胞吞噬功能

耳肿增重法观察小鼠迟发型超敏反应

溶血素抗体测定法观察小鼠溶血素抗体生成。结果: 熄风静宁汤高、中剂量能明显提高免疫功能低下小鼠的碳粒廓清指数和吞噬指数

拮抗环磷酰胺诱导的免疫低下小鼠耳肿胀度减轻

高剂量能提高免疫低下小鼠溶血素抗体生成。结论: 熄风静宁汤对小鼠的非特异性免疫、特异性细胞免疫和体液免疫反应有促进作用。

Abstract

Objective: To study the effect of Xifeng Jingning Tang on immunologic function in mice with immunodepression. Method: The immunodepression mice model was induced by intraperitoneal injection of cyclophosphamide with 50 mg ·kg-1. Mice were administrated with Xifeng Jingning Tang at doses of 3

12 g ·kg-1 for 7 days.The phagocytic activity of monocytes

the delayed hypersensitivity reaction and the haemolysin antibody formation in mice were observed by means of carbon particle clearance

ear swelling and haemolysin antibodies respectively. Result: The doses of 6 and 12 g ·kg-1 ·d of Xifeng Jingning Tang could improve immune function in mice shown by carbon clearance index

phagocytic index and ear swelling. Xifeng Jingning Tang 12 g ·kg-1 could increase content of haemolysin antibody induced by cyclophosphamide. Conclusion: Xifeng Jingning Tang can improve non-specific immunity

and enhance specific cellular immunity and humoral immune function in immunodepression mice induced by cyclophosphamide.

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