Novel paeonol para-substitution derivatives were synthesized with the natural resources paeonol and p-nitro-benzaldehyde

p-methyl benzaldehyde

p-fluorobenzaldehyde

and discussed those reaction mechanisms

This research will provide scientific proof. Methods: Novel paeonol para-substitution derivatives were synthesized in alkaline medium with the natural resources paeonol and p-nitro-benzaldehyde

p-methyl benzaldehyde

p-fluorobenzaldehyde respectively at room temperature

three novel compounds structures were characterized by IR

UV

MS

1H-NMR

13C-NMR

135° DEPT

X-ray structure analysis.and elemental analysis. Those crystal structures of 3-hydroxy-1-(2-hydroxy-4-methoxy phenyl)-3-(4 '-nitrobenzene)-1-acetone and 2-hydroxy-4-methoxy-4'-methylchalcone were also characterized by X-ray structure analysis. Results: The reaction of paeonol and p-nitro-benzaldehyde is by aldol condensation reaction

and paeonol and p-methyl benzaldehyde

or p-fluorobenzaldehyde is by Claisen-Schmidt condensation reaction. The crystal of 3-hydroxy-1-(2-hydroxy-4-methoxy phenyl)-3-(4 '-nitrobenzene)-1-acetone belongs to triclinic crystallographic system

space group p_1_21/c_1 and cell parameters: a=0.875 0(15)nm

b=1.137 8(2) nm

c=1.554 0(3)nm

α=90.0(8) °

β=106.5(8) °

γ=90(8) °

V=1.483 5(5) nm3

Dc=1.41 6mg ·m-3

μ=0.110 mm-1

F(000)=660

Z=4

R1=0.059 5

ωR2=0.185 3

R(int)=0.021 9. The crystal 2-hydroxy-4-methoxy-4'-methylchalcone belongs to triclinic crystallographic system

space group P2(1)/n and its cell parameters: a=1.137 7(3) nm

b=0.683 7(17) nm

c=2.043 0(4) nm

α=90.0(10)°

β=117.7(10)°

γ=90(10) °

V=1.406 4(6)nm3

Dc=1.416 mg ·m-3

μ=0.086 mm-1

F(000)=568

Z=4

R1=0.045 2

ωR2=0.122 5

R(int)=0.021 5. Conclusion: Different type paeonol derivatives were synthesized in alkaline medium with the natural resources paeonol and p-nitro-benzaldehyde

p-methyl benzaldehyde

p-fluorobenzaldehyde respectively at room temperature by different reaction mechanisms.