Immuno-regulation Effects of Wuzi Yanzong Decoction on Immunosuppression Mice

WANG Hong-wu; JIA Liang-liang; XU Yuan-qing; LI Shou-chao; ZENG Xiao; HE Yu-min; AI Hong; YUAN Ding; ZHANG Chang-cheng

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Immuno-regulation Effects of Wuzi Yanzong Decoction on Immunosuppression Mice

更新时间：2024-09-23

- Immuno-regulation Effects of Wuzi Yanzong Decoction on Immunosuppression Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 4, Pages: 144-146(2011)
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- Published：2011
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WANG Hong-wu, JIA Liang-liang, XU Yuan-qing, et al. Immuno-regulation Effects of Wuzi Yanzong Decoction on Immunosuppression Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 144-146.
DOI：

WANG Hong-wu, JIA Liang-liang, XU Yuan-qing, et al. Immuno-regulation Effects of Wuzi Yanzong Decoction on Immunosuppression Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 144-146. DOI：

摘要

目的 :研究五子衍宗汤对环磷酰胺致免疫低下小鼠的免疫调节作用。方法: 将实验用Balb/C小鼠32只

雌雄各半

随机分为空白组、模型组、五子衍宗汤低、高剂量组

每组8只。空白组ip生理盐水

其余各组小鼠ip环磷酰胺50 mg ·kg-1 ·d-1建立免疫低下模型。空白组和模型组灌胃生理盐水

五子衍宗汤低、高剂量组分别按照2

4 g ·kg-1剂量灌胃五子衍宗汤。给药35 d后

观察五子衍宗汤对模型小鼠外周血象、体重、脾脏指数、骨髓有核细胞数量和脾脏淋巴细胞数量的影响

流式细胞术检测脾脏中CD3+

CD4+

CD8+

CD19+

NK细胞的绝对数量。结果 :造模结束后

模型组小鼠外周血白细胞数、脾细胞绝对数量、相对数量、骨髓有核细胞数量及脾脏中CD3+

CD4+

CD8+

CD19+

NK细胞的数量低于空白组

差异有统计学意义( P ﹤0.01或 P ﹤0.05)。五子衍宗汤能显著增加模型小鼠体重、脾重、外周血白细胞数、骨髓有核细胞数及脾脏中CD3+

CD4+

CD8+

CD19+

NK细胞的数量

差异有统计学意义( P ﹤0.01或 P ﹤0.05)。结论 : 五子衍宗汤可显著增强环磷酰胺所致免疫低下小鼠的免疫功能。

Abstract

Objective: To investigate the immune regulatory effect of Wuzi Yanzong decoction on immunosuppression mice. Method: Thirty two Balb/C mice

half male and femal

were divided into four groups.Three groups of mice were administered Cy ip (50 mg ·kg-1 once a day for 5 days)to induce immunosuppression; two of these groups received Wuzi Yanzong decoction treatment (2

4 g ·kg-1 orally once a day for 35 days; 5 days after Cy ip).A vehicle treated control group was also included.The body weight and spleen weight were measured.The absolute number of total splenocytes and bone marrow cells was analyzed.The absolute number of CD3+T cells

CD4+T cells

CD8+ T cells

B cells and NK cells in spleen was detected by flow cytomety. Result :Cy-treated mice showed a significant decrease in the number of leukocytes on peripheral blood

total splenocytes

bone marrow cells and the absolute number of CD3+T cells

CD4+T cells

CD8+ T cells

B cells and NK cells in spleen.Wuzi Yanzong decoction significantly increased the number of leukocytes in peripheral blood

antagonist the loss of immune organ and body weight

restore the number of leukocytes

bone marrow nucleated cells

total splenocytes and improved the ratio and number of CD3+T cells

CD4+T cells

CD8+ T cells

B cells and NK cells in spleen. Conclusion: Wuzi Yanzong decoction markly improves the immune function in immunodepressed mice induced by Cy.

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Related Author

WANG Hong-wu1

JIA Liang-liang1

XU Yuan-qing1

LI Shou-chao1

ZENG Xiao1

HE Yu-min1

AI Hong2

YUAN Ding1

Related Institution

Medical College of China Three Gorges University

The First College of Clinical Medical Seience,Three Gorges University,department of Clinical Laboratory,Yichang Central People’s Hospital

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Shaanxi University of Chinese Medicine

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

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