Influence of Zhongfeng Zaobei Huatan Jiaonang on Nerve Protection and Vascular Endothelial Growth Factor Expression in Cerebral Ischemia-Reperfusion Injury in Rats
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Influence of Zhongfeng Zaobei Huatan Jiaonang on Nerve Protection and Vascular Endothelial Growth Factor Expression in Cerebral Ischemia-Reperfusion Injury in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 3, Pages: 138-141(2011)
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Published:2011
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WANG Bao-liang, HAN Yan-li. Influence of Zhongfeng Zaobei Huatan Jiaonang on Nerve Protection and Vascular Endothelial Growth Factor Expression in Cerebral Ischemia-Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 138-141.
DOI:
WANG Bao-liang, HAN Yan-li. Influence of Zhongfeng Zaobei Huatan Jiaonang on Nerve Protection and Vascular Endothelial Growth Factor Expression in Cerebral Ischemia-Reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 138-141.DOI:
Influence of Zhongfeng Zaobei Huatan Jiaonang on Nerve Protection and Vascular Endothelial Growth Factor Expression in Cerebral Ischemia-Reperfusion Injury in Rats
Objective: To observe the effect of Zhongfeng Zaobei Huatan Jiaonang(ZFZBHTJN) on nerve protection and the VEGF expression in cerebral ischemia-reperfusion injury rats model. Method: Fifty SD rats were randomly divided into sham operation group
ischemia-reperfusion (I-R) group
ZFZBHTJN high
Medium
low dose group(1.62
1.08
0.54 g \5kg-1 \5d-1). The rat model of cerebral ischemia-reperfusion was produced by Zea-longa method. The impacts of ZFZBHTJN on neuro logic function and expression of VEGF were obseved. Result: Compared with sham operation group
I-R group presented severe neuro logic deficits and increases of VEGF expression in cortex and hippocampus.Compared with those in I-R group
neuro logic deficits of rats were relieved significantly and VEGF expression increased distinctly in ZFZBHTJN groups. High dose group (1.62 g \5kg-1 \5d-1) presented the most significant effect on nerve protection (P<0.01). Conclusion: ZFZBHTJN may relive cerebral ischemia-reperfusion injury in rats by increasing VEGF expression.
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