Objective: To investigate pharmacokinetics for paeoniflorin of Fuyankang enema in rabbits and provide scientific basis for clinical application. Method: The pharmacokinetic study of paeoniflorin after rectal administration and administration by gavage with single dose was investigated by using above HPLC method respectively

the pharmacokinetics parameters was calculated with 3p97 programs. Result: Administration by gavage

the paeoniflorin wasn’t detected in the rabbit plasma by HPLC method established and the pharmacokinetic parameter of wasn’t obtained. After rectal administration

the curve of paeoniflorin plasma concentration-time could be described by a one-compartment model

correlation pharmacokinetic parameter described as follows: ka was 3.190 9 h

ke was 0.943 8 h

t1/2(ka)was 0.217 2 h

t1/2(ke)was 0.734 4 h

Tmax was 0.542 1 h

Cmax was 5.239 7 mg ·L-1

AUC0-4h was 9.260 2(mg ·L-1) ·h. Conclusion: The result indicated the absorption of paeoniflorin after rectal administration Fuyankang enema is much more superiority to administration by gavage.