Effect of Prescriptions of Reinforcing Spleen on PKC, Bcl-2 and Bax Protein Expression in Spleen in Rats
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Effect of Prescriptions of Reinforcing Spleen on PKC, Bcl-2 and Bax Protein Expression in Spleen in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 6, Pages: 206-208(2011)
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Published:2011
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FENG Xiao-fan, ZHANG Li-de. Effect of Prescriptions of Reinforcing Spleen on PKC, Bcl-2 and Bax Protein Expression in Spleen in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 206-208.
DOI:
FENG Xiao-fan, ZHANG Li-de. Effect of Prescriptions of Reinforcing Spleen on PKC, Bcl-2 and Bax Protein Expression in Spleen in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(6): 206-208.DOI:
Effect of Prescriptions of Reinforcing Spleen on PKC, Bcl-2 and Bax Protein Expression in Spleen in Rats
Objective: To explore the change of the expression of apoptotic regulatory protein PKC
Bcl-2 and Bax in spleens of spleen deficiency rats. Method: Sixty SPF rats were divided equally into five groups.Expression of Bcl-2 and Bax in spleens was studied by immunohistochemistry method. Result: Compared to the control group
the expression of Bcl-2 was markedly lower in the model group. Compared to the model group
the level of Bcl-2 was significantly increased while levels of Bax and PKC was significantly decreased. Conclusion: Effect mechanism of Spleen-Invigorating recipe on spleen deficiency may be related to the incresed of Bcl-2 as well as the decrese of Bax and PKC.