Preparation of Hawthorn Leaves Total Flavonoids Dispersible Tablets

ZUO An-gang; ZHOU Ying; LI Li; WANG Hui-juan

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Preparation of Hawthorn Leaves Total Flavonoids Dispersible Tablets

更新时间：2024-01-04

- Preparation of Hawthorn Leaves Total Flavonoids Dispersible Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 11, Pages: 26-29(2011)
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- Published：2011
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ZUO An-gang, ZHOU Ying, LI Li, et al. Preparation of Hawthorn Leaves Total Flavonoids Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 26-29.
DOI：

ZUO An-gang, ZHOU Ying, LI Li, et al. Preparation of Hawthorn Leaves Total Flavonoids Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 26-29. DOI：

摘要

目的: 筛选山楂叶总黄酮分散片的制剂处方。方法: 以崩解时间为考察指标

考察不同种类的辅料及其用量

采用正交试验设计确定最佳处方。结果: 分散片最优处方为16%山楂叶提取物

55% MCC

8% cCMC-Na

18%淀粉

1%硬脂酸镁

其崩解时间为(66±5)s。结论: 研制的山楂叶总黄酮分散片处方合理

体外溶出度明显优于市售普通片剂

是值得开发的产品。

Abstract

Objective: To screen the optimal formula for total flavonoids dispersible tablets of hawthorn leaves. Method: Different kinds of excipients in the prescription were selected and their amount was optimized by using disintegration time as parameters.The optimal composition of the prescription was determined by orthogonal design experiment. Result: The optimal formulation was as follows:16% total flavonoids extracts of hawthorn leaves

55% MCC

8% cCMC-Na

18% starch and 1% magnesium stearate.The disintegration time of dispersible tablet was (66±5)s. Conclusion: The dispersible tablet had reasonable prescription and its dissolution rate was much better than the common tablet of hawthorn leaves total flavonoids in the market.It would be a product worthy of exploitation and utilization.

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Related Author

LI Peng

ZHANG Yu-yan

LI Jin-hui

XING Pan-ke

WAN Hai-tong

YANG Jie-hong

ZHOU Ying

LIANG Guang-yi

Related Institution

Department of National Drug Clinical Trials,The First Hospital of Lanzhou University

College of Pharmaceutical Science, Lanzhou University

College of Life Science and Engineering,Lanzhou University of Technology

Department of Pharmacology,School of Basic Medicine,Capital Medical University

The Second People’s Hospital of Gansu Province

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