Study on Rat Intestinal Absorption of Match-pair of Coptis-Evodia

TU Yao-sheng; SUN Dong-mei; ZENG Xiao-hui; CHEN Yu-xin; HUANG Xue-jun

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Study on Rat Intestinal Absorption of Match-pair of Coptis-Evodia

更新时间：2024-01-04

- Study on Rat Intestinal Absorption of Match-pair of Coptis-Evodia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 11, Pages: 116-119(2011)
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- Published：2011
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TU Yao-sheng, SUN Dong-mei, ZENG Xiao-hui, et al. Study on Rat Intestinal Absorption of Match-pair of Coptis-Evodia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 116-119.
DOI：

TU Yao-sheng, SUN Dong-mei, ZENG Xiao-hui, et al. Study on Rat Intestinal Absorption of Match-pair of Coptis-Evodia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(11): 116-119. DOI：

摘要

目的: 研究黄连吴茱萸不同配比的在体肠吸收

比较不同配比在不同肠段吸收系数的异同。方法: 采用大鼠在体单向肠灌流模型

以HPLC测定灌流后药液浓度

考察黄连与吴茱萸不同配比对小肠吸收和转运的影响。结果: 黄连吴茱萸6 ∶6在空肠的吸收常数比其他肠段要大

差异有显著性(P<0.05);黄连吴茱萸6 ∶1在空肠和回肠的吸收常数比其他肠段大

差异显著(P<0.05)。黄连吴茱萸1 ∶1在空肠、回肠及结肠的吸收速率常数Ka值比十二指肠大

在回肠的表观吸收系数Kapp值比其他肠段要大(P<0.05);黄连吴茱萸2 ∶1、黄连吴茱萸6 ∶1及吴茱萸单煎在回肠的吸收常数较其他肠要大(P<0.05)。在回肠中黄连吴茱萸2 ∶1吸收较其他2个比例药物要好(P<0.05);在结肠中黄连吴茱萸各比例吸收没有吴茱萸单煎好(P<0.05)。结论: 黄连和吴茱萸无论单煎或不同比例组方在各肠段均有吸收

其中黄连 ∶吴茱萸为1 ∶1和6 ∶1时于空肠和回肠较易吸收;黄连 ∶吴茱萸为2 ∶1时较易于回肠吸收。

Abstract

Objective: To study the intestinal absorption of the different match-pair of Coptis-Evodia

to compare the intestinal absorption rate and absorption coefficient. Method: Single pass perfusion models in rats and HPLC were used to study the concentration and absorption coefficients of match-pair of Coptis-Evodia

to study the absorption and transport in the small intestine. Result: The absorption rate of Coptis-Evodia 6 ∶6 were the largest in jejunum as Coptis-Evodia 6 ∶1 were the largest in Jejunum and Ileum

the difference was significant (P<0.05).The Ka of Coptis-Evodia 1 ∶1 in jejunum

kleum and colon was larger than that in Duodenum as the Kapp was the largest in ileum;the absorption rate of Coptis-Evodia 2 ∶1 and 6 ∶1 in ileum were larger than the other intestine

the difference was significant (P<0.05).The absorption rate of Coptis-Evodia 2 ∶1 in lleum were larger than the other match-pair

the difference was significant (P<0.05). Conclusion: Coptis-Evodia 1 ∶1 and 6 ∶1 were better absorpted in jejunum and ileum

Coptis-Evodia 2 ∶1 was better absorpted in ileum.

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