Objective: To optimize the separation and purification of total phenolic acids from salvia by polyamide resins. Method: Based on absorptive capacity and elution efficiency of total phenolic acids in salvia

the conditions to separate and purify total phenolic acids in salvia were determined. Result: The polyamide resin (60-100 meshes) was chosen

washed with 40% ethanol

and the optimal concentration was 3.5 mg ·mL-1. The purity of total phenolic acids obtained was 98.41%. Conclusion: Using polyamide resin (60-100 meshes) to separate and purify total phenolic acids from salvia is feasible.