Objective: To prepare total Dracocephalum moldevica flavonoids osmotic pump tablets and study its factors influencing on drug release in vitro. Method: The UV spectrophotometer was used to determine the release of the osmotic pump tablets

and various factors affected the drug release were studied. Result: The type and amount of penetration enhancers

the amount of sodium bicarbonate

and the coating weight had significant effects on release in vitro. Conclusion: The preparation of osmotic pump tablet is reasonably and stable and the formulations can meet the requirement of the controlled release drug delivery.