Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin

DENG Hang; HE Min; LI Jiang; LUO Xu-yan; HUNG Ren-bin

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Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin

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- Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 4, Pages: 114-117(2011)
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- Published：2011
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DENG Hang, HE Min, LI Jiang, et al. Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 114-117.
DOI：

DENG Hang, HE Min, LI Jiang, et al. Hypoglycemic Effect of Persimmon Leaf Polysaccharide in Diabetic Mice Induced by Streptozotocin[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 114-117. DOI：

摘要

目的 :研究柿叶多糖对链脲佐菌素糖尿病小鼠的降血糖作用及其作用机制。方法 :将实验小鼠随机分成5组:正常对照组、模型组、格列本脲组(25 mg ·kg-1 ·d-1)

柿叶多糖低、高剂量组(150

600 mg ·kg-1 ·d-1)。ig给于药物15 d

并在相应时间采血测定空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素敏感指数(ISI)、丙二醛(MDA)、超氧化歧化酶(SOD)等指标。结果 :高剂量的柿叶多糖能较明显的改善糖尿病小鼠的葡萄糖耐量(P<0.01)

低、高剂量组均能显著降低糖尿病小鼠的血糖水平(P<0.05)

有效降低肝组织MDA值

相应增高SOD活力

并能显著增加胰岛素敏感指数(ISI)

改善胰岛素抵抗状态。结论 : 柿叶多糖具有较强的降血糖作用

可能与其能提高小鼠肝脏抗氧化酶活性、改善胰岛素抵抗等有关。

Abstract

Objective: To investigate the hypoglycemic effect and its action mechanism of persimmon leaf polysaccharide in diabetic mice induced by streptozotocin (STZ). Method: The diabetic mice were induced by STZ.Mice were randomly divided into 5 groups: control group

model group

glibenclamide group (25 mg ·kg-1 ·d-1)

low and high dose groups of persimmon leaf polysaccharide (150 mg ·kg-1 ·d-1

600 mg ·kg-1 ·d-1).The drugs were administrated to mice in every morning for 15 days.In the corresponding time

the contents of fasting blood glucose (FBG)

fasting insulin(FINS)

malondialdehyde (MDA)

superoide dismutase (SOD) activity

insulin sensitivity index (ISI) and oral glucose tolerance test (OGTT) were determined. Result: The persimmon leaf polysaccharide could markedly decrease blood glucose in STZ-induced diabetic mice.Meanwhile it could reduce the content of MDA and increase the activity of SOD in liver

and increase insulin sensitivity index (ISI) and the amount of islet cells. Conclusion: The persimmon leaf polysaccharide decreases blood glucose

and it has a very potential value in the treatment of diabetes.

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Related Author

DENG Hang1

HE Min1

LI Jiang1

LUO Xu-yan1

HUNG Ren-bin1

YUAN Yue

GAO Yunxiao

ZHANG Qiuyan

Related Institution

Pharmaceutical School,Guangxi Medical University

Affiliated Hospital of Guilin Medical College

Institute of Basic Medical Sciences，Beijing Key Laboratory of Chinese Materia Pharmacology， National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases， Xiyuan Hospital，China Academy of Chinese Medical Sciences

People’ Hospital of Wuxuan,Wuxuan

No.454 Hospital of People’s Liberation Army

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