Effects of Tetramethylpyrazine Injection on Angiogenesis and Expression of VEGF mRNA in Ischemic Myocardium of Rats with Myocardial Infarction
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Effects of Tetramethylpyrazine Injection on Angiogenesis and Expression of VEGF mRNA in Ischemic Myocardium of Rats with Myocardial Infarction
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 7, Pages: 170-173(2011)
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Published:2011
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ZHANG Shu-juan, WANG Zhen-tao, HAN Li-hua, et al. Effects of Tetramethylpyrazine Injection on Angiogenesis and Expression of VEGF mRNA in Ischemic Myocardium of Rats with Myocardial Infarction[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 170-173.
DOI:
ZHANG Shu-juan, WANG Zhen-tao, HAN Li-hua, et al. Effects of Tetramethylpyrazine Injection on Angiogenesis and Expression of VEGF mRNA in Ischemic Myocardium of Rats with Myocardial Infarction[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 170-173.DOI:
Effects of Tetramethylpyrazine Injection on Angiogenesis and Expression of VEGF mRNA in Ischemic Myocardium of Rats with Myocardial Infarction
Objective: To observe the effects of tetramethylpyrazine injection on the angiogenesis and expression of vascular endothelial growth factor(VEGF)mRNA in ischemic myocardium of the rats with myocardial infarction(MI). Method :The left coronary artery of male Wistar rat was ligated to make the model of acute myocardial infarction.All rats were randomly divided into Tetramethylpyrazine injection group
Shexiang Baoxin Pills group(positive control group)
model group and sham operation group. Microvasscular vascular density(MVD) and VEGF mRNA in ischemic myocardium of rats with MI were detected six weeks later. Result :MVC and MVD in ischemic myocardium of rats with MI in modle group
tetramethylpyrazine injection group and Shexiang Baoxin Pills group were higher than that in sham operation group.In tetramethylpyrazine injection group they were the same as Shexiang Baoxin Pills group
which were higher than that in modle group.The expression of VEGFmRNA in modle group were elevated compared with that in sham operation group.It was significantly elevated in tetramethylpyrazine injection group compared with that in modle group and lower than that in Shexiang Baoxin Pills group. Conclusion :tetramethylpyrazine injection may promote angiogenesis in ischemic myocardium of the rats with MI.One of the mechanisms might be that tetramethylpyrazine injection could promot the expression of VEGFmRNA in ischemic myocardium of the rats with MI.
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