Laboratory Observation of Chronic Heart Failure of Shenfu Yixin Granule in Rats
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Laboratory Observation of Chronic Heart Failure of Shenfu Yixin Granule in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 4, Pages: 118-120(2011)
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Published:2011
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WANG Yong-xia, REN Hong-jie, ZHU Ming-jun, et al. Laboratory Observation of Chronic Heart Failure of Shenfu Yixin Granule in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 118-120.
DOI:
WANG Yong-xia, REN Hong-jie, ZHU Ming-jun, et al. Laboratory Observation of Chronic Heart Failure of Shenfu Yixin Granule in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(4): 118-120.DOI:
Laboratory Observation of Chronic Heart Failure of Shenfu Yixin Granule in Rats
Objective: To observe the effect of the Shenfu Yixin Granule on chronic heart failure rats. Method: The chronic heart failure model was established by left anterior descending coronary artery occlusion.in sham operation group (n=20) the sutures were passed under the left anterior descending coronary artery without ligation.After 8 weeks the chronic heart failure rats with the value of left ventricle ejection fraction(LVEF) <50% were randomly assigned to 5 groups (n=10 in each group):model group
captopril group
losartan group
two groups of Shenfu Yixin Granule(5.475
21.9 g ·kg-1 ·d-1).All the medicine was given through gavage once a day for 4 weeks
the rats in model group and sham operation group were administered with equivalent water once a day for 4 weeks.After 4 weeks The LVEF was valued again with Color Doppler Ultrasound
Weighs were measured.The blood was collected to detection index. Result: Shenfu Yixin granule(21.9 g ·kg-1 ·d-1) improved the LVEF obviously
lowered the left ventricular mass index(LVMI) serum ANP and
serum BNP. Conclusion: Shenfu Yixin granule can cure chronic heart failure evidently and may intervene ventricular remodeling.