Experimental Study of Intervention of Buyang Huanwu Decoction on Metabolic Syndrome and von willebrand Factor

CUI Han-bo; HAN Tao; ZHANG Dong-yu; JU Fei-fei

您当前的位置：

首页 >

文章列表页 >

Experimental Study of Intervention of Buyang Huanwu Decoction on Metabolic Syndrome and von willebrand Factor

更新时间：2024-01-04

- Experimental Study of Intervention of Buyang Huanwu Decoction on Metabolic Syndrome and von willebrand Factor
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 7, Pages: 173-175(2011)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2011
- 稿件说明：
移动端阅览
CUI Han-bo, HAN Tao, ZHANG Dong-yu, et al. Experimental Study of Intervention of Buyang Huanwu Decoction on Metabolic Syndrome and von willebrand Factor[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 173-175.
DOI：

CUI Han-bo, HAN Tao, ZHANG Dong-yu, et al. Experimental Study of Intervention of Buyang Huanwu Decoction on Metabolic Syndrome and von willebrand Factor[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 173-175. DOI：

摘要

目的: 观察补阳还五汤干预代谢综合征(MetS)模型血管性血友病因子(vWF)的作用和初步探讨其机制。方法: 52只雄性Wistar大鼠随机分为正常、模型对照、补阳还五汤、补阳还五汤去黄芪方4组

采用高糖脂餐加链脲佐菌素建立MetS模型

补阳还五汤组按7.02 g ·kg-1 ig

1次/d给药

补阳还五汤去黄芪方组按1.07 g ·kg-1 ig

1次/d给药

造模和给药同时进行并持续8周

观察补阳还五汤及其去黄芪方对空腹血糖(FBG)

血清胰岛素(Ins)

稳态模型评价胰岛素抵抗(HOMA-IR)和血清vWF水平的影响。结果: 模型组Ins

HOMA-IR

vWF较正常组明显升高(P<0.05);与模型组比较

补阳还五汤组的Ins

HOMA-IR

vWF明显降低(P<0.05);补阳还五汤去黄芪方组Ins

HOMA-IR与模型组比较无统计学差异

FBG明显升高(P<0.01)

vWF明显降低(P<0.05)。结论: 补阳还五汤能够改善MetS模型的胰岛素抵抗和降低vWF水平;方中黄芪是改善胰岛素抵抗的有效成分

6味活血药是降低vWF的有效成分。

Abstract

Objective: To study the interventive affect and mechanism of Buyang Huanwu decoction (BYHW decoction) on von Willebrand factor (vWF) of animal with metabolic syndrome(MetS). Method: Rats were distributed randomly into 4 groups: empty control

model control

BYHW decoction group

BYHW decoction without Astragali Radix group. To set up pathological modal of MetS

rats were given streptozotocin (STZ) and feed with high-fat and high-carbohydrate diet. Dose: BYHW decoction group 7.02 g ·kg-1 ig

BYHW decoction without Astragali Radix group 1.07 g ·kg-1 ig. Both were once a day. Experiment lasts for 8 weeks. Fasting blood glucose (FBG)

insulin(Ins)

homeostasis model assessment-insulin resistance(HOMA-IR) and vWF in serum were observed. Result: Compared with blank control

Ins

HOMA-IR and vWF were higher in model group (P<0.05). Compared with model

BYHW decoction group was lower in Ins

HOMA-IR and vWF(P<0.05); BYHW decoction without Astragali Radix group was higher in FBG (P<0.01)

no evident differences in Ins

HOMA-IR

and lower in vWF. Conclusion: BYHW decoction might prevent IR and reduce vWF. Astragali Radix is the effective part in preventing IR and six other drugs may reduce vWF.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Observation of Modified Huanglian Wendantang in Treatment of Cardiovascular Risk Factors in Patients with Metabolic Syndrome Under Guidance of Treating Disease before Its Onset

Effect and Mechanism of Prunellae Spica on Metabolic Syndrome in Rats

Effect of Qingfei Xiegantang on Chronic Inflammation and Endothelial Function with Metabolic Syndrome

Mechanism of Pinelliae Rhizoma-Citri Exocarpium Rubrum in Treatment of Metabolic Syndrome Based on Network Pharmacology

Pathogenesis of Metabolic Syndrome from "Qi of five Internal Organs"

Related Author

HAN Yi

HAN Yubo

ZOU Guoliang

WANG Ruinan

YAO Chunli

DONG Xinyu

LIU Li

LI Li

Related Institution

First Affiliated Hospital of Heilongjiang University of Chinese Medicine

Heilongjiang University of Chinese Medicine

Hunan University of Chinese Medicine

Hunan Brain Hospital （The Second People's Hospital of Hunan Province）

Medical College of Yanbian University，Yanbian

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰