Influence of Intramedullary Given with Injection on Osteoclast of Steroid-induced Necrosis of Femoral Head in Rabbit
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Influence of Intramedullary Given with Injection on Osteoclast of Steroid-induced Necrosis of Femoral Head in Rabbit
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 18, Pages: 176-178(2010)
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Published:2010
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WA Qing-de, ZHANG Tian-hong, LI Zhen-wei, et al. Influence of Intramedullary Given with Injection on Osteoclast of Steroid-induced Necrosis of Femoral Head in Rabbit[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 176-178.
DOI:
WA Qing-de, ZHANG Tian-hong, LI Zhen-wei, et al. Influence of Intramedullary Given with Injection on Osteoclast of Steroid-induced Necrosis of Femoral Head in Rabbit[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 176-178.DOI:
Influence of Intramedullary Given with Injection on Osteoclast of Steroid-induced Necrosis of Femoral Head in Rabbit
Objective: To copy the rabbit model of necrosis of the femoral head
observe the number of osteoclasts
study the feasibility and mechanism of intramedullary injection with Salvia miltiorrhiza injection for preventing of steroid-induced necrosis of the femoral head at the molecular level. Method: Thirty rabbits were randomly divided into three groups: control group
model group
prevention group
10 in each group. Glucocorticoid-induced rabbit model of femoral head necrosis was prepared. While making the models
the prevention group has received bone marrow cavity intramedullary injection with Salvia miltiorrhiza. at a dose of 0.4 mg ·kg-1 twice a week for 8 weeks. 8 weeks later
the number of osteoclasts and histopathological changes in three groups of rabbits were observed. Result : The prevention group could effectively reduce the number of osteoclasts and the rate of empty lacunae femoral head. Conclusion : Salvia miltiorrhiza injection plays a good effective role in the prevention of steroid-induced avascular necrosis of femoral head through inhibitting osteoclast formation.