Chemical Constituents of Maimendong plus Qianjin Weijing Decoction

LI Wei; TANG Yu-ping; GAO Hao-xue; ZHANG Xu; DING An-wei; DUAN Jin-ao

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Chemical Constituents of Maimendong plus Qianjin Weijing Decoction

更新时间：2024-09-23

- Chemical Constituents of Maimendong plus Qianjin Weijing Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 18, Pages: 78-81(2010)
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- Published：2010
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LI Wei, TANG Yu-ping, GAO Hao-xue, et al. Chemical Constituents of Maimendong plus Qianjin Weijing Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 78-81.
DOI：

LI Wei, TANG Yu-ping, GAO Hao-xue, et al. Chemical Constituents of Maimendong plus Qianjin Weijing Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 78-81. DOI：

摘要

目的 :研究麦门冬合千金苇茎汤效应部位的化学成分。方法 :采用有机溶剂提取

反复硅胶柱色谱和重结晶法进行分离纯化

根据化合物的理化性质和波谱数据鉴定其结构。结果 :从麦门冬合千金苇茎汤乙酸乙酯部位分离得到12个化合物

分别鉴定为:芒柄花素 (formononetin

1)、甘草素 (liquiritigenin

2)、异甘草素 (isoliquiritigenin

3)、20(R)-人参皂苷Rg3 、丁二酸 (succinic acid

5)、异香草酸 (isovanillic acid

6)、尿嘧啶 (uracil

7)、琥珀酸酐 (succinic anhydride

8)、甘露醇 (D-mannitol

9)、对羟基苯甲酸 (p-hydroxybenzoic acid

10)、β-谷甾醇 (β-sitosterol

11)、豆甾醇 (stigmasterol

12)。结论 :所得成分大部分来源于甘草、人参、半夏、苇茎;根据文献报道分析

其中化合物1~4可能是该合方治疗肺癌的效应物质基础。

Abstract

Objective: To study the chemical constituents of Maimendong plus Qianjin Weijing decoction. Method: The constituents were isolated by column chromatography and their structures were elucidated by physico-chemical properties and spectroscopic analysis. Result : Twelve compounds were isolated and identified as formononetin (1)

liquiritigenin (2)

isoliquiritigenin (3)

20(R)-ginsenoside Rg3 (4)

succinic acid (5)

isovanillic acid (6)

uracil (7)

succinic anhydride (8)

D-mannitol (9)

p-hydroxybenzoic acid (10)

β-sitosterol (11)

stigmasterol (12). Conclusion : Most of the constituents were come from Radix Glycyrrhiza

Radix Ginseng

Rhizoma Pinelliae and Rhizoma Phragmites

and compounds 1-4 may be responsible for lung cancer therapeutic action of the formula on the basis of literature reports.

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Related Author

TANG Yu-ping

GAO Hao-xue

ZHANG Xu

DING An-wei

DUAN Jin-ao

LI Wei

JIA Tian-zhu

ZHOU Ling

Related Institution

Jiangsu Key Laboratory for Traditional Chinese Medicine Formulae Research,Nanjing University of Chinese Medicine

Pharmacy College,Chengdu University of Traditional Chinese Medicine

the Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine

State Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese Medicine Resources

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