Effect of Compound Modified Sini Powder on Expression of Type Ⅰ and Type Ⅲ Collagen in Schistosoma Japonicum-infected Mice
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Effect of Compound Modified Sini Powder on Expression of Type Ⅰ and Type Ⅲ Collagen in Schistosoma Japonicum-infected Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 16, Pages: 178-181(2010)
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Published:2010
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CAI Rui, LI Shan, WU Can-rong, et al. Effect of Compound Modified Sini Powder on Expression of Type Ⅰ and Type Ⅲ Collagen in Schistosoma Japonicum-infected Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 178-181.
DOI:
CAI Rui, LI Shan, WU Can-rong, et al. Effect of Compound Modified Sini Powder on Expression of Type Ⅰ and Type Ⅲ Collagen in Schistosoma Japonicum-infected Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 178-181.DOI:
Effect of Compound Modified Sini Powder on Expression of Type Ⅰ and Type Ⅲ Collagen in Schistosoma Japonicum-infected Mice
Objective: To observe the effect of compound modified SiNi powder(JWSNS) on liver fibrosis in Schistosoma japonicum-infected Mice. Method: The NIH mice were successfully induced to liver fibrosis by infection with S. japonicum and then randomly divided into groups B
C
D and E.The mice in groups C
D and E were treated with praziquantel
praziquantel plus JWSNS and praziquantel plus colchicine
respectively.In addition
a group of unfected NIH mice(group A) served as normal control.Histological specimens were stained with HE.Expression of type Ⅰ and type Ⅲ collagen were determined by Immunohistochemistry(IHC). Result: The protein levels of type Ⅰ and type Ⅲ collagen in praziquantel plus JWSNS group(group D) were significantly lower than those in model group(grop B)
praziquantel group(group C) and praziquantel plus colchicine group(group E)(P<0.05).These findings showed JWSNS can reduced the hepatic expression of type Ⅰ and type Ⅲ collagen in mice with liver fibrosis. Conclusion: JWSNS combined with praziquantel can decrease the expression of type Ⅰ and type Ⅲ collagen and implove liver fibrosis due to S. japonicum.
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