Objective: To investigate the effect of extract from Sedum lineare Thunb (SLT) on lipid peroxidation in rat with hepatic fibrosis. Method: Male SD rats were divided into six groups randomly. The hepatic fibrosis model was induced by intragastric administration with 50% carbon tetrachloride dissolved in peanut oil. Once the model was formed

the rat was administrated with various doses of SLT (4 g ·kg-1

8 g ·kg-1) or NS through intragastric pathway

and the process was lasted for 9 weeks. After the last administration

the rats blood and liver are taken under anesthesia. The cellular structure and grade of hepatic fibrosis were observed by histological method

as well as the content and activity of MDA

SOD

GSH-Px in serum and hepatic tissue were detected. Result: In the model group

severe degeneration and necrosis of hepatic cells

significant accumulation of collagen fibers was observed

the level of MDA in hepatic tissue and serum was increased

and the activity of SOD and GSH-Px was decreased obviously. After treated with SLT

degeneration and necrosis of hepatic cells and the grade of hepatic fibrosis were inhibited

the level of MDA was descended

and the activity of SOD and GSH-Px was enhanced significantly. Conclusion: SLT has a therapeutic effect on hepatic fibrosis in rats

the mechanism is possibly related with alleviation of the injury induced by lipid peroxidation.