Comparative Study on Content of Saikosaponin Substances and Acute Toxicity of Radix Bupleuri and its Processed Products
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Comparative Study on Content of Saikosaponin Substances and Acute Toxicity of Radix Bupleuri and its Processed Products
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 13, Pages: 190-193(2010)
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Published:2010
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SUN Rong, HUANG Wei, YIN Jian-wei, et al. Comparative Study on Content of Saikosaponin Substances and Acute Toxicity of Radix Bupleuri and its Processed Products[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 190-193.
DOI:
SUN Rong, HUANG Wei, YIN Jian-wei, et al. Comparative Study on Content of Saikosaponin Substances and Acute Toxicity of Radix Bupleuri and its Processed Products[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 190-193.DOI:
Comparative Study on Content of Saikosaponin Substances and Acute Toxicity of Radix Bupleuri and its Processed Products
Objective: To compare the content of saikosaponin and the acute toxicity on Radix Bupleuri and its processed products
and discuss the effect of processing on the content and toxicity of Bupleurum saikosaponin substances. Method: HPLC method and the classical method of acute toxicity were used to determine the content of saikosaponin a and the acute toxicity of the Radix Bupleuri and its processed products
and compare the content and the acute toxicity. Result: The content of saikosaponin a on the different processed products which included health products
fried products
vinegar products
wine products and honey roasted products was separately 0.60%
0.23%
0.56%
0.39%
0.35%. The health products
fried products
vinegar products
wine products and honey roasted products of Radix Bupleuri did not appear dead. Calculated by crude drug content
the MLD were respectively 26.4
31.2
27.6
28.8
32.4 g ·kg-1
which were respectively equal to 205
242
214
224
252 times of 70 kg people’s daily dried medicinal herb expenses. Making continuous observation of 14 days
mice were generally in good condition
and no one died. Conclusion: The content of saikosaponin a and the acute toxicity of the Radix Bupleuri and its processed products were different
and no death occurred in each sample
the MLD showed the basic security and low toxicity of the Radix Bupleuri and its processed products
suggesting that processing has some influence on the content of the saikosaponin substances and the safe dose range of Radix Bupleuri herbs.
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Related Institution
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