Selection on Optimal Molding Technology of Waiganfengsha Sugarless Granules by Orthogonal Design
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Selection on Optimal Molding Technology of Waiganfengsha Sugarless Granules by Orthogonal Design
Chinese Journal of Experimental Traditional Medical FormulaeVol. 17, Issue 3, Pages: 11-13(2011)
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Published:2011
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LIU Yuan-huan, WU Yu-qiang, JIANG Lin, et al. Selection on Optimal Molding Technology of Waiganfengsha Sugarless Granules by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 11-13.
DOI:
LIU Yuan-huan, WU Yu-qiang, JIANG Lin, et al. Selection on Optimal Molding Technology of Waiganfengsha Sugarless Granules by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 11-13.DOI:
Selection on Optimal Molding Technology of Waiganfengsha Sugarless Granules by Orthogonal Design
Objective: To select the optimal molding technology of Waiganfengsha sugarless granules. Method: Orthogonal design of L9 (34) was used with composite score of formalizing properties
color uniformity
solubility and moisture percentage as the judgement criteria to screen out the kinds and ratio of the excipients and optimal preparation process. Result: The optimum conditions was A2B2C2
that was 1.75 times of mixing excipients; the mixed composition of excipients was dextrin-MCC-stevia hormone (94 ∶5 ∶1); the wetting agent was 90% alcohol. The factors to be affected in descending order were A>C>B ; among the factors
A and C of the granulation comprehensive score was significant ( P <0.05). Conclusion: The molding technology was stable and reasonable