Optimal Extraction of Effective Constituents from Radix Salvia Based on Central Composite Design/Response Surface Methodology

HUANG Yuan-hong; WEI Tian-xi; ZHANG Fa-sheng; YANG Jun-xuan

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Optimal Extraction of Effective Constituents from Radix Salvia Based on Central Composite Design/Response Surface Methodology

更新时间：2024-01-04

- Optimal Extraction of Effective Constituents from Radix Salvia Based on Central Composite Design/Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 17, Pages: 28-31(2010)
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- Published：2010
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HUANG Yuan-hong, WEI Tian-xi, ZHANG Fa-sheng, et al. Optimal Extraction of Effective Constituents from Radix Salvia Based on Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 28-31.
DOI：

HUANG Yuan-hong, WEI Tian-xi, ZHANG Fa-sheng, et al. Optimal Extraction of Effective Constituents from Radix Salvia Based on Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 28-31. DOI：

摘要

目的 :星点设计-效应面法优选丹参的提取工艺。方法 :以丹参酮ⅡA和丹酚酸B提取率

收膏率为考察指标

采用星点设计考察提取乙醇用量、提取时间以及乙醇浓度对提取工艺的影响

对结果进行多元线性回归和二项式拟合

用效应面法选择较佳工艺条件

并进行预测分析。结果 :复相关系数上看

各项指标二项式拟合方程均优于多元线性回归方程

确定最优提取工艺为加9倍量60%乙醇提取3次

每次1.5 h

提取量预测值与理论值偏差小于3%。结论 :星点设计-效应面法优选丹参的提取工艺

方法简便

预测性良好。

Abstract

ObJective: To optimize the process of extracting effective constituents from Radix Salvia by central composite design/response surface methodology. Method: The effects of influence factors such as solvent fold

ethanol concentration and extract time on extraction rate of tanshinone Ⅱa and salvianolic acid were investigated by using box-behnken design and response surface method. The data were imitated using multi-linear equation and second-order polynomial equation. Result: Multiple correlation coefficients from second-order polynomial equation were prior to those from multi-linear equation. The optimum condition of extraction process was 9 fold solvent

1.5 hours for decoction

and 3 times for extraction; the ethanol concentration was 60%. Bias between observed and predicted values was less than 3%. Conclusion: The optimum model was highly predictive.

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Related Author

LIU Chang-qing

XIE You-liang

LAI Xiao-ping

YU Yang

ZHOU Li-ling

WEI Min

LI Xiu-mei

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Related Institution

College of Pharmacy,Shenyang Pharmaceutical University

College of Pharmacy,Heilongjiang University of Chinese Medicine

广州中医药大学广东广州510405

Guangzhou of TCM

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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