Influence of Huanglian Jiedu Decoction on NF-κB and TNF-α of Liver in Diabetic Rats
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Influence of Huanglian Jiedu Decoction on NF-κB and TNF-α of Liver in Diabetic Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 18, Pages: 153-156(2010)
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Published:2010
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Chen Hong, SUN Ming-jie, PENG Juan, et al. Influence of Huanglian Jiedu Decoction on NF-κB and TNF-α of Liver in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 153-156.
DOI:
Chen Hong, SUN Ming-jie, PENG Juan, et al. Influence of Huanglian Jiedu Decoction on NF-κB and TNF-α of Liver in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 153-156.DOI:
Influence of Huanglian Jiedu Decoction on NF-κB and TNF-α of Liver in Diabetic Rats
Objective: To study the influence of Huanglian Jiedu Decoction on NF-κB
TNF-α of liver in diabetic rats
explore therapeutic mechanism of Huanglian Jiedu Decoction on diabetes. Method: The rat diabetic model was made by high fat diet and small doze of streptozotocin (STZ).After giving Huanglian Jiedu Decoction (11.5
5.7
2.85 g ·kg-1)for 8 weeks
FGB
CHO
TG
LDLC and HDLC were measure
the liver and pancreas mass indexes were calulated.Using the immunohistochemical methods the contents of NF-κB and TNF-α in the liver of rats were determined. Result: High-dosage group and middle-dosage group of Huanglian Jiedu Decoction could significantly decrease the contents of CHO
TG
LDLC in rat serum
increase the contents of HDLC
lower the liver and pancreas mass indexes obviously.The expression of NF-κB
TNF-α in the liver was lower in the treatment groups compared with that in the model group. Conclusion: Huanglian Jiedu Decoction has therapeutic effect on diabetic rats induced by high fat diet and small doze of streptozotocin. The mechanism might be related to regulating the expression of NF-κB