Optimization of Formulation of Huanglian-Jiedu Bioadhesive Microspheres by Central Composite Design

ZANG chen; NIE Qi-xia; WANG Guo-hua; ZHANG Bao-xian; LI Hui

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Optimization of Formulation of Huanglian-Jiedu Bioadhesive Microspheres by Central Composite Design

更新时间：2024-01-04

- Optimization of Formulation of Huanglian-Jiedu Bioadhesive Microspheres by Central Composite Design
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 17, Pages: 21-25(2010)
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- Published：2010
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ZANG chen, NIE Qi-xia, WANG Guo-hua, et al. Optimization of Formulation of Huanglian-Jiedu Bioadhesive Microspheres by Central Composite Design[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 21-25.
DOI：

ZANG chen, NIE Qi-xia, WANG Guo-hua, et al. Optimization of Formulation of Huanglian-Jiedu Bioadhesive Microspheres by Central Composite Design[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 21-25. DOI：

摘要

目的 :确定黄连解毒黏附微球的最佳处方工艺。方法 :以成品收率

小檗碱、栀子苷、黄芩苷包封率

微球在人工胃液中的黏度为指标

采用中心组合设计法优化黄连解毒黏附微球的处方工艺

对结果进行二项式拟合

对最优条件进行预测分析。结果 :各指标二项式方程拟合度较好

按处方优化得到最佳条件制备黄连解毒黏附微球

各项指标与预测值接近。结论 :中心组合设计法优化黏附微球工艺条件准确、可靠。

Abstract

ObJective: To optimize the formulation of Huanglian-Jiedu bioadhesive microspheres. Method: The optimum formulation was investigated by central composite design with five responses ie. yield

entrapment efficiency of three effective ingredients and mucoadhesive property. The data were imitated using second-order polynomial equation

and the numerical optimization was performed. Result: Prepare microspheres with optimum formulation

and the responses approached the prediction at the optimum. Conclusion: The performulation and preparation of microspheres were reasonable and reliable.

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