Anti-inflammatory and Analgesic Effects of Jingangteng's Effective Ingredients on Chronic Pelvic Inflammation

HUANG Xian-zhang; ZOU Peng-cheng; GAO Qiu-fang; FENG Yun; YIN Ling; LIU Yan-wen

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Anti-inflammatory and Analgesic Effects of Jingangteng's Effective Ingredients on Chronic Pelvic Inflammation

更新时间：2024-01-04

- Anti-inflammatory and Analgesic Effects of Jingangteng's Effective Ingredients on Chronic Pelvic Inflammation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 17, Pages: 114-117(2010)
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- Published：2010
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HUANG Xian-zhang, ZOU Peng-cheng, GAO Qiu-fang, et al. Anti-inflammatory and Analgesic Effects of Jingangteng's Effective Ingredients on Chronic Pelvic Inflammation[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 114-117.
DOI：

HUANG Xian-zhang, ZOU Peng-cheng, GAO Qiu-fang, et al. Anti-inflammatory and Analgesic Effects of Jingangteng's Effective Ingredients on Chronic Pelvic Inflammation[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 114-117. DOI：

摘要

目的: 确定金刚藤治疗慢性盆腔炎的有效物质部位群

为金刚藤制剂的二次开发提供实验依据。方法: 采用苯酚胶浆注入大鼠子宫造成大鼠慢性盆腔炎模型

探讨金刚藤有效物质部位群对慢性盆腔炎模型大鼠子宫炎症的影响;采用二甲苯致小鼠耳肿胀法和鸡蛋清水溶液致大鼠足跖肿胀法探讨其抗炎作用;采用小鼠扭体法观察其镇痛作用;采用酶联免疫法检测大鼠子宫组织中前列腺素E2(PGE2)的含量。结果: 金刚藤有效物质部位群能明显减轻慢性盆腔炎模型大鼠子宫的炎症反应;能明显减轻小鼠耳肿胀及大鼠足跖肿胀反应;能明显减少小鼠的扭体次数;可显著降低大鼠子宫组织中PGE2的含量。结论: 金刚藤有效物质部位群对大鼠和小鼠致炎模型具有显著的治疗作用

在小鼠扭体实验中表现出良好的镇痛作用

金刚藤有效部位群抑制PGE2的合成及释放是其发挥抗炎作用的机制之一。

Abstract

ObJective: To study the pharmacodynamic actions of Jingangteng's effective ingredients(JEIS) on chronic pelvic inflammation disease (CPID)and to provide experimental evidence for Jingangteng's further development. Method: The models of CPID were made by inJection of brei admixed with phenol and tragacanth into the uterus of rats

and the inhibitory effect on CPID was observed. The severity of oedema in inflammation was observed to study the anti-inflammatory effects of JEIS. The analgesic effect of the drug was studied with pain model of mice induced by acetic acid

the PGE2 contents in the uterus in CPID rats were measured by enzyme-linked immunosorbent assay (ELISA). Result: JEIS could obviously inhibit the inflammation of uterus in rats with CPID. The number of stretching induced by acetic acid was reduced and the pain threshold of mice was increased by JEIS. JEIS also had anti-inflammatory activity against xylene-induced mouse ear swelling and albumen-induced rat paw edema. JEIS could significantly decrease the level of PGE2

in the uterus of CPID rats. Conclusion: JEIS has significant analgesic and anti-inflammatory activities

and decreasing of PGE2 may be one of the anti-inflammation mechanisms of JEIS.

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