Correlation between Tumor Necrosis Factor- and Uveitis

LUO Yi

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Correlation between Tumor Necrosis Factor- and Uveitis

更新时间：2024-01-04

- Correlation between Tumor Necrosis Factor- and Uveitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 17, Pages: 211-213(2010)
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- Published：2010
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LUO Yi. Correlation between Tumor Necrosis Factor- and Uveitis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 211-213.
DOI：

LUO Yi. Correlation between Tumor Necrosis Factor- and Uveitis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 211-213. DOI：

摘要

目的 :探讨肿瘤坏死因子-α(TNF-α)与葡萄膜炎发病的相关性。方法 :采用多聚酶链反应技术检测60例葡萄膜炎及60例正常人外周血TNF-α水平及其基因多态性。结果 :观察组外周血中TNF-α水平明显高于对照组(P<0.05);观察组经PCR扩增后可见特异性TNF-α扩增产物

TNF-α基因目的片段大小为117 b;对照组未见特异性TNF-α扩增产物;经PCR/RFLP分析发现两组TNF-α基因有3种酶切格局

即TNFα-308A/A纯合子的标本不发生酶切、TNFct-308G/G纯合子发生完全酶切;TNFα-308G/A杂合子产生部分酶切;两组基因型频率从高到低依次为G/G型、G/A型、A/A型

但两组比较具有明显差异(P<0.05)。结论 :肿瘤坏死因子TNF-α与葡萄膜炎的发病具有显著的相关性。

Abstract

ObJective: To investigate the correlation between tumor necrosis factor-α (TNF-α) and t uveitis. Method :The polymerase chain reaction was employed to detect 60 cases of uveitis

peripheral blood TNF-α level and gene polymorphism were also determined. Result :TNF-α in peripheral blood was significantly higher (P<0.05) in observation group. After PCR amplification

TNF-α gene fragment of the size of 117b was found; The control group no specific amplification products. PCR/RFLP analysis showed that Group 2 TNF-α gene had three kinds of restriction patterns

i.e. TNFα-308A/A homozygous without digestion

TNFct-308G/G homozygotes with completed digestion and TNFα-308G/A heterozygote produces with partial digestion. Had genotype frequencies from the high to the generation were in the order of G/G type

G/A-type

A/A type. But the two groups had significant difference (P<0.05). Conclusion : TNF-α and the incidence of uveitis are correlated.

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