Experiment Research of Shutong Capsule on Defecating Function with Coprostasis Type of Dry Stagnation in Stomach and Intestines
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Experiment Research of Shutong Capsule on Defecating Function with Coprostasis Type of Dry Stagnation in Stomach and Intestines
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 18, Pages: 139-141(2010)
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Published:2010
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ZENG Qun, ZHAO Guo-yi. Experiment Research of Shutong Capsule on Defecating Function with Coprostasis Type of Dry Stagnation in Stomach and Intestines[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 139-141.
DOI:
ZENG Qun, ZHAO Guo-yi. Experiment Research of Shutong Capsule on Defecating Function with Coprostasis Type of Dry Stagnation in Stomach and Intestines[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 139-141.DOI:
Experiment Research of Shutong Capsule on Defecating Function with Coprostasis Type of Dry Stagnation in Stomach and Intestines
观测舒通胶囊高、中、低剂量ig对正常小鼠、燥结便秘小鼠首便时间和4h内粪点数的影响;观测舒通胶囊ig对正常大鼠、燥结便秘大鼠大肠推进运动影响。 结果 :疏通胶囊对正常小鼠和大鼠的排便没有影响。燥结便秘小鼠首便时间和4h内粪点数各给药组与模型组相比均有显著差异( P <0.01或 P <0.05)
其中以舒通胶囊高剂量组作用最强( P <0.001);在大肠推进速度和推进率方面
舒通胶囊高、中剂量组与模型组相比有显著性差异( P <0.001或 P <0.01)。 结论 :舒通胶囊对燥结失水型便秘有润肠通便、增强大肠推进率的作用。
Abstract
Objective: To study the effect of Shutong Capsule on defecating function with type of dry stagnation in stomach and intestines. Method: Through feeding with rice and prohibition of drinking water three days
we prepared the rat model and mouse model with coprostasis type of dry stagnation in stomach and intestines. And then
using Shutong Capsule (high
medium and low dosage
ig) as the treatment
first time of defecation and grains of defecation in 4h for normal mice and dry stool constipation mice
and periotalsis of intestine for normal rats and dry stool constipation rats were all observed and recorded. Result: There were no impact on purgation for normal mice and rat.There were significant differences between all the drug groups and model group in first time of defecation and grains of defecation in 4h of mice ( P <0.01 or P <0.05).The effect of Shutong high
medium dosage group was more evident than that in the low one ( P <0.001). Shutong high
medium dosage group were significantly increased comparing with model group in the pushing length and percentage of rat intestine ( P <0.001 or P <0.01). Conclusion: Shutong Capsule can moisten intestines and urge purgation
increase the peristalic rate of intestine for type of dry stagnation in stomach and intestines.