ObJective: To make the optimum process conditions of extraction for Fulin granules. Method: Orthogonal design was used for the optimum extraction of Fulin granules with paeoniflorin and dry-paste as marker. Result: Optimum processing condition was as follows: water reflux-extraction three times with 10 folds water for 2 h

8 folds water for 1 h and 8 folds water for 1 h respectively. Conclusion: This method is simple and can be applied rightly in mass production.