Effects of Salvianolic Acid B and Paeonol Drug Combination on Rats Isolated Vasorelaxant Activity and Acute Myocardial Ischemia-reperfusion InJury

JIN Kang; KAN Hong-wei; SHI Jing-li; WANG Hai-qing; XU Peng-fu; LIANG Yan; YANG Shi-you; TIAN Jun

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Effects of Salvianolic Acid B and Paeonol Drug Combination on Rats Isolated Vasorelaxant Activity and Acute Myocardial Ischemia-reperfusion InJury

更新时间：2024-01-04

- Effects of Salvianolic Acid B and Paeonol Drug Combination on Rats Isolated Vasorelaxant Activity and Acute Myocardial Ischemia-reperfusion InJury
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 17, Pages: 197-201(2010)
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- Published：2010
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JIN Kang, KAN Hong-wei, SHI Jing-li, et al. Effects of Salvianolic Acid B and Paeonol Drug Combination on Rats Isolated Vasorelaxant Activity and Acute Myocardial Ischemia-reperfusion InJury[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 197-201.
DOI：

JIN Kang, KAN Hong-wei, SHI Jing-li, et al. Effects of Salvianolic Acid B and Paeonol Drug Combination on Rats Isolated Vasorelaxant Activity and Acute Myocardial Ischemia-reperfusion InJury[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 197-201. DOI：

摘要

目的 :观察丹酚酸B和丹皮酚不同配比组合对大鼠离体胸主动脉血管的舒张作用和急性心肌缺血再灌注损伤的保护作用。方法: 采用基线等比增减设计法进行药物配比设计

观察不同配比组合对去甲肾上腺素、氯化钾诱导的大鼠收缩血管环的舒张效应;结扎心脏左冠状动脉前降支(LAD)制备急性心肌缺血再灌注损伤模型

观察不同药物组合对心电图(ECG)、心肌梗死面积(MIS)、血清丙二醛(MDA)、一氧化氮(NO)、超氧化物歧化酶(SOD)和肌酸激酶同工酶(CK-MB)的影响。结果: 丹酚酸B和丹皮酚各配比组合对离体血管舒张效果明显高于模型组

可减少再灌注损伤造成的心肌梗死面积

降低缺血程度(∑-ST)

提高血清中SOD活力和NO含量

降低MDA含量和CK-MB水平;不同组合以丹酚酸B和丹皮酚之比为3 ∶1药物组合效果最佳。结论: 丹酚酸B和丹皮酚配比组合对大鼠血管具有一定的舒张作用以及对大鼠急性心肌缺血再灌注损伤具有较好的保护作用

丹酚酸B和丹皮酚之间可能存在一定的协同或相加作用。

Abstract

ObJective: The effects of the different Salvianolic acid B (Sal B) and Paeonol (Pae) drug combinations on isolated vascular and acute myocardial ischemia-reperfusion inJury (MI/RI) were investigated in rats. Method: A increase-decrease design method of experiment with baseline geometric proportion was established to design Salvianolic acid B and Paeonol drug combinations. The changes in isometric tension were recorded by force transducers connected to the system. Vaso-relaxant effects of the drug combinations were observed on the contraction of rat thoracic aorta rings. Acute myocardial ischemia model was made by ligation of left anterior descending artery in the anesthetized open chest rats.Changes in baseline geometric was designed for the different combinations

the effects of different combinations on electrocardiogram(ECG)

myocardial infarction square(MIS)

malondialdehyde(MDA)

superoxide dismutase(SOD)and nitrogen monoxidum(NO) were measured

and effects on isoenzyme of creatine-kinase(CK-MB) were also determined. Result : The drug combinations on vasorelaxant activity was superior to model group and can reduce the degree of myocardial ischemia(∑-ST) and the infarction square(MIS)

Moreover

it also can reduce MDA and CK-MB in serum

and improve SOD and NO activity in MI/RI. The ratio of 3 ∶1 was the best in the drug combinations. Conclusion :The drug combinations of Sal B and Pae have some protective effects on acute myocardial ischemia-reperfusion inJury in rats. Some synergistic or additive effects may exist between Sal B and Pae.

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