Antitumor and Apoptosis Inducement Effects of Petroleum Ether Extract from Pine Needles

TANG Hong-qin; ZHOU Wei; NING Tao-li; WANG Xiao-lan; ZHENG Xiao-ke

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Antitumor and Apoptosis Inducement Effects of Petroleum Ether Extract from Pine Needles

更新时间：2024-09-23

- Antitumor and Apoptosis Inducement Effects of Petroleum Ether Extract from Pine Needles
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 11, Pages: 177-179(2010)
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- Published：2010
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TANG Hong-qin, ZHOU Wei, NING Tao-li, et al. Antitumor and Apoptosis Inducement Effects of Petroleum Ether Extract from Pine Needles[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 177-179.
DOI：

TANG Hong-qin, ZHOU Wei, NING Tao-li, et al. Antitumor and Apoptosis Inducement Effects of Petroleum Ether Extract from Pine Needles[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 177-179. DOI：

摘要

目的: 探讨松针石油醚提取物抗肿瘤作用机制。方法: 建立荷S180实体瘤小鼠模型

考察松针石油醚提取物体内抗肿瘤作用。应用免疫组化法检测肿瘤组织中凋亡相关蛋白Bax

Bcl-2的表达。结果: 松针石油醚提取物0.5

1.0

2.0 g·(kg·d) -1 3个剂量组对S180实体瘤的抑瘤率分别为31.16%

41.71%

42.16%。各用药组肿瘤组织Bax表达显著增强

Bcl-2表达显著降低。结论: 松针石油醚提取物具有一定的抗肿瘤活性

诱导凋亡是其机制之一。

Abstract

Objective: To study the antitumor mechanism of petroleum ether extract of pine needles. Method: Antitumor activity of the petroleum ether extract was determined by means of transplantable tumor (S180) in mice. Immunohistochemical methods were employed for detection of Bax

Bcl-2 in tumor tissues. Result: The inhibition rate of peftroleum ether extract2.0 g·(kg·d) -1 on S180-bearing mice was 42.16%. As for 1.0 g·(kg·d) -1 and 0.5 g·(kg·d) -1 groups

the inhibition rates were 41.71% and 31.16%. Expression of Bax in tumors was obviously increased and Bcl-2 was obviously decreased in all the therapy groups compared with the tumor control group (P<0.01). Conclusion: Petroleum ether extract from pinee needles possesses definite antitumor effect.

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Related Author

TANG Hong-qin 1

ZHOU Wei2

NING Tao-li2

WANG Xiao-lan1

ZHENG Xiao-ke1

DAI Ting

CHEN Yan

GUO Changsheng

Related Institution

Henan University of Traditional Chinese Medicine

Henan Engineering Research Center of Development of Traditional Chinese Medicine

The First Affiliated Hospital of Henan University of Chinese Medicine

The First Clinical Medical School of Henan University of Chinese Medicine

Graduate School of Heilongjiang University of Chinese Medicine

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