Objective: To investigate therapeutic effects of total saponins extracted from leaves of rehmannia on C-BSA in rat. Method: Cationized bovine serum albumin(C-BSA) was prepared.For establishing nephritis in rat

C-BSA was given to rat by injection through tail venule.Total saponins extracted from leaves of rehmannia were orally given to the model rats as treatment for 28 days at doses of 20~40 mg ·kg-1.Blood biochemeical parameters

urine protein and pathological changes of nephritis were employed to evaluate the efficacy of the treatment. Result: Compared with the model rats

urinary protein

serum urea nitrogen

cholesterol and creatinine were significantly increased. The pathological changes of nephritis were alleviated. Conclusion: Total saponins extracted from leaves of rehamannia has therapeutic effect with a dose-response manner on C-BSA nephritis in rat.