Effect of Yinxieping Granules on Guinea Pig Model of Psoriasis

LI Tao; LI Hong-mei; LI Xiao-qin; SUN Jian-hui; QIU Xiang-yan; ZHOU Ai-xiang

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Effect of Yinxieping Granules on Guinea Pig Model of Psoriasis

更新时间：2024-01-04

- Effect of Yinxieping Granules on Guinea Pig Model of Psoriasis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 16, Pages: 137-139(2010)
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- Published：2010
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LI Tao, LI Hong-mei, LI Xiao-qin, et al. Effect of Yinxieping Granules on Guinea Pig Model of Psoriasis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 137-139.
DOI：

LI Tao, LI Hong-mei, LI Xiao-qin, et al. Effect of Yinxieping Granules on Guinea Pig Model of Psoriasis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 137-139. DOI：

摘要

目的 :研究银屑平颗粒对豚鼠银屑病模型的影响。方法 :采用心得安乳剂涂抹耳造豚鼠银屑病样模型

银屑平高、中、低剂量ig 2周

处死豚鼠

采用ELISA试剂盒检测豚鼠耳匀浆液中肿瘤坏死因子-α(TNF-α)及细胞间黏附因子(ICAM-1)的含量

并观察其对病理形态学的影响。结果 :与正常组比较

模型组豚鼠TNF-α及ICAM-1显著升高(P<0.05)

与模型组比较

银屑平颗粒高、中剂量组、甲氨喋呤组TNF-α及ICAM-1显著降低(P<0.01);与模型组比较

银屑平高、中、低剂量组对心得安所致的表皮皮损、红肿

皮肤糜烂

角化不全

毛细血管增生扩张等形态学改变有不同程度的改善。结论 :银屑平颗粒对银屑病有良好的治疗作用。

Abstract

Objective: To study the effect of Yinxieping Granules on guinea pig model of psoriasis. Method: All guinea pigs were coated propranolol emulsion on the ear twice a day for 2 weeks to establish the model of psoriasis.Then the granules was given daily by oral gavage for 2 weeks.Guinea pigs were sacrificed when the experiment was done.Tumor necrosis factor-α (TNF-α) and cell adhesion molecule (ICAM-1)were determined in the ear homogenates by ELISA kit. Result: Compared with the normal group

TNF-α and ICAM-1 were significantly higher in the model group(P<0.05).Compared with the model group

TNF-α and ICAM-1 were significantly lower in each of the treatment group(P<0.01). Conclusion: Yinxieping granules is a effective treatment for psoriasis.

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Related Institution

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