Distribution of Administrated Resveratrol-loaded Solid Lipid Nanoparticles in Mice
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Distribution of Administrated Resveratrol-loaded Solid Lipid Nanoparticles in Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 13, Pages: 183-185(2010)
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Published:2010
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LIANG Jian-qin, LIU Hua-gang. Distribution of Administrated Resveratrol-loaded Solid Lipid Nanoparticles in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 183-185.
DOI:
LIANG Jian-qin, LIU Hua-gang. Distribution of Administrated Resveratrol-loaded Solid Lipid Nanoparticles in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 183-185.DOI:
Distribution of Administrated Resveratrol-loaded Solid Lipid Nanoparticles in Mice
Objective: To investigate the distribution of resveratrol-loaded solid lipid nonoparticles (Res-SLN) in mice. Method :Res-SLN was prepared by heat-high pressure homogenization method. Distribution studies were accomplished in mice. At different time after tail iv administration at 115.50 mg ·kg-1 for Res-SLN group and at 119.25 mg ·kg-1 for Res-Sus group
the animals were sacrificed (n=5 animals for each time). Tissues were collected
washed
weighted and analyzed. Result: Distribution study in mice demonstrated that Res after administrated Res-SLN was mainly distributed in liver and kidney. Compared to the control group
the target efficiency of Res-SLN was 1.82 folds in kidney. On the other hands
the Res retention time after administrated Res-SLN was prolonged. Conclusion: Res-SLN is an effective preparation that can target Res to kidney in mice.
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Related Institution
School of Pharmacy,Guangdong Pharmaceutical University
School of Life Sciences and Biopharmaceutics,Guangdong Pharmaceutical University
School of Basic Medical Sciences, Guangzhou University of Chinese Medicine
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State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Center of Efficient Utilization of Natural Medicine Resources, High Educational Key Laboratory of Natural Medicinal Pharmacology and Druggability of Guizhou Province, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University