Anti-alcoholism and Liver Protection Effects of Yangyuan Yin on Alcoholic Liver Injury in Rats

WU Cheng; LV Zhu-hai; SHEN Cun-si; NONG Wei-hu; XU Hui-qin

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Anti-alcoholism and Liver Protection Effects of Yangyuan Yin on Alcoholic Liver Injury in Rats

更新时间：2024-09-23

- Anti-alcoholism and Liver Protection Effects of Yangyuan Yin on Alcoholic Liver Injury in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 14, Pages: 150-153(2010)
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- Published：2010
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WU Cheng, LV Zhu-hai, SHEN Cun-si, et al. Anti-alcoholism and Liver Protection Effects of Yangyuan Yin on Alcoholic Liver Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 150-153.
DOI：

WU Cheng, LV Zhu-hai, SHEN Cun-si, et al. Anti-alcoholism and Liver Protection Effects of Yangyuan Yin on Alcoholic Liver Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 150-153. DOI：

摘要

目的: 观察养元饮对酒精性肝损伤大鼠解酒和保肝作用。方法: 通过连续6周ig食用酒建立酒精性肝损伤大鼠模型

给酒的同时ig给予养元饮。气相色谱法检测血清中乙醇和乙醛含量

肝脏中乙醇脱氢酶(ADH)活力和血清中丙氨酸氨基转移酶(ALT)

天门冬氨酸氨基转移酶(AST)活性使用比色法测定

取适量肝脏HE染色

在光学显微镜下进行病理学检查。结果: 养元饮中、高剂量能明显降低血清中乙醇和乙醛含量

其中高剂量可显著提高肝脏中ADH水平

作用优于海王金樽。养元饮同时有降低血中ALT和AST活性作用。结论: 养元饮主要通过提高ADH活性降低乙醇浓度

同时防止肝脏转氨酶入血从而达到保护肝细胞作用。

Abstract

Objective: To study the effect of Yangyuan Yin on decreasing alcohol in blood and protecting liver after drinking alcohol. Method: The model of alcoholic liver injury in rats was established by giving alcohol ig for 6 weeks. Meanwhile

Yangyuan Yin was given to the rats in the treatment group. By the end of the 6th week

alcohol content in blood was determined by GC

colorimetry was applied to determine ADH activity in liver and ALT

AST in blood serum. Result: Middle and high doses of Yangyuan Yin could significantly reduce the levels of alcohol and acetaldehyde in blood. Actually

the high dose could significantly improve the level of liver ADH

better than that of Haiwangjinzun. Actually

compared to the model

the activity of ALT and AST was decreased by the treatment. Conclusion: Yangyuan Yin is able to decrease alcohol in blood after drinking alcohol. The effects may be achieved by increasing the level of liver ADH.

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Related Author

XU Hui-qin1

NONG Wei-hu1

SHEN Cun-si1

LV Zhu-hai2

WU Cheng1

LV Ji-hua

DENG Yu-yin

LIU Ying

Related Institution

Department of pharmacology,Nanjing University of Chinese Medicine

Neurosurgery of Nanjing Brain Hospital

Jiangxi Provincial Key Laboratory of Drug Design and Evaluation，School of Pharmacy， Jiangxi Science and Technology Normal University

Key Laboratory of Modern Chinese Medicine Preparation，Ministry of Education， Jiangxi University of Traditional Chinese Medicine

Changchun University of Chinese Medicine

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