Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice

ZHANG Ran; YUE Yong-hua; KANG Yong; SUN Guo-dong; LI Hui-juan; JIAN Xiao-yong; WANG Liu-gui; QIN Xia

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Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice

更新时间：2024-09-23

- Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 18, Pages: 135-138(2010)
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- Published：2010
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ZHANG Ran, YUE Yong-hua, KANG Yong, et al. Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 135-138.
DOI：

ZHANG Ran, YUE Yong-hua, KANG Yong, et al. Immue-improving Effect of Fuzheng Guben Granule Combined with Radiotherapy and Chemotherapy on Tumor-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 135-138. DOI：

摘要

目的 :研究扶正固本颗粒联合化疗、放疗的体内抗肿瘤作用及对荷瘤小鼠免疫功能的影响

并与单独放疗、化疗作比较。方法 :建立小鼠肉瘤S180移植性肿瘤模型

次日随机分为10组

放、化疗

并ig给药每日1次

10 d后

计算抑瘤率、胸腺指数和脾指数

测定细胞因子白介素-2(IL-2)

白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平和外周血细胞数量

检测其抑瘤作用及对荷瘤小鼠免疫功能的影响。结果 :联合治疗较单独的放化疗能增强荷瘤小鼠腹腔巨噬细胞吞噬功能

提高荷瘤小鼠的胸腺指数和脾脏指数;拮抗化疗所致荷瘤小鼠血清IL-2

IL-6 和TNF-α的减少;拮抗放疗所致荷瘤小鼠外周血细胞的减少。结论 :联合治疗可增强荷瘤小鼠免疫功能。

Abstract

Objective: To investigate the anti-tumor and immune effect of Fuzheng Guben Granule combined with chemotherapy and radiotherapy in tumor-bearing mice. Method: Tumor-bearing model of S180 sarcoma in mice was established by subcutaneous injection of S-180 ascites at armpit. On the next day

the mice were randomly divided into 10 groups

Fuzheng Guben Granule with radio- and chemotherapy was carried out once a day for ten days. Tumor inhibitory percentage

thymus gland

spleen indexes were then measured. The determination of cytokine

such as IL-2

IL-6

TNF-α and peripheral blood cell counts was made. The effect of treatment on tumor inhibition and immunological function was studied. Result: The combined therapy could significantly increase thymus gland

spleen indexes and improved the phagocytic function;antagonize serum IL-2

IL-6 and TNF-α reduction induced by chemotherapy;suppress the decrease in peripheral blood cells count induced by radiotherapy. Conclusion: Combinative therapy can enhance immune functions for S180-bearing mice.

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Related Author

YUE Yong-hua1

KANG Yong1

SUN Guo-dong1

LI Hui-juan

JIAN Xiao-yong2

WANG Liu-gui2

QIN Xia3

ZHANG Ran1

Related Institution

Traditional Chinese Medicine Institute of Shanxi Province

Shanxi Zhendong Kaiyuan Pharmaceutical Co.,Ltd.

Hospital of Taiyuan University of Technology

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