Objective: To discuss the molecular mechanism of Ease Powder decoction treating on sleep deprivation depression by observing the changes of autonomic-behavior and the expression of serum TT3

TT4

FT3

FT4

TSH in a rat experimental model of sleep deprivation depression(SDD). Method: Fouty eight Wistar rats were divided into four groups after first open-field testing (OFT)

they were normal group

model group

mirtazapine group and Ease Powder decoction group. Except the normal group

the other groups were received different stress for 21 days.Making day stress before 1 h the model group

mirtazapine

Ease Powder decoction group were intragastric administration of normal saline

mirtazapine

Ease Powder decoction respectively.At the end of 21 days

all the animals were sacrificed.The serum of rats was taken then kept in -20 ℃ freezer and the levels of TT3

TT4

FT3

FT4 and TSH were determined. Result: Compared with the situation before SDD

there was a significant decrease in the autonomic-behavior (P<0.01) of SDD after 21 days.Compared with the model group

the autonomic-behavior of Ease Powder decoction group and the mirtazapine group was increased(P<0.01).Compared with the normal group

there was no difference.The expression of serum TT3 and TT4 was no differences between the groups.However

compared with that in the nomal group

the expression of FT3 in the model group was decreased

FT4 was increased

TSH was nochange. Compare with the model group

the mirtazapine group and Ease Powder decoction group had no statistically significant

while the nomal group has statistically significant(P<0.05). Conclusion: The Ease Powder decoction exert an effect on SDD.However

The Ease Powder decoction has no influence on the expression of thyroxine.