Objective: To observe effects of Jiangtang xiaozhi Tablets on decreasing levels of blood glucose in rat and mouse models of diabetes mellitus. Method: Rats were intravenously given streptozotocin at dose of 50 mg ·kg-1.Mice were intravenously given Alloxan at dose of 90 mg ·kg-1to induce hyperglycemia.The levels of blood glucose in the rats and mice were measured after 3 days for screening model animals.Thereafter

rats were divided into 7 groups ( n =12

each) and were continuously given Jiangtang xiaozhi tablets by intragastric administration for 8 weeks.The levels of blood glucose

HBAlc

insulin and glucagon were assayed.While mice were divided into 7 groups ( n =14

each) and were continuously given Jiangtang xiaozhi tablets by intragastric administration for 4 weeks.The level of blood glucose was assayed. Result: The levels of blood glucose in each Jiangtang xiaozhi treatment group

HBAlc and glucagon levels in high dose group were significantly decreased (P<0.05) comparing to those of model rats while serum insulin levels were increased in the high dose group.The morphological study of pancreas in rats demonstrated that number of islets markedly increased in the high dose group.The levels of blood glucose in mice were significantly decreased (P<0.05-0.001) in middle and high dose groups comparing to that of model mice. Conclusion: Jiangtang xiaozhi Tablets has obvious effect on decreasing blood glucose for model animals of diabetes mellites.